Human CDR-grafted antibody and antibody fragment thereof

Details Human CDR-grafted antibody and antibody fragment thereof Human CDR-grafted antibody and antibody fragment thereof

2009-02-27

2010-11-30

Allen, Marianne P (Department: 1647)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C530S387100

Reexamination Certificate

active

07842797

ABSTRACT:
A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4 and has a cytotoxic activity against a CCR4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.

REFERENCES:
patent: 6488930 (2002-12-01), Wu et al.
patent: 6989145 (2006-01-01), Shitara et al.
patent: 2002/0098527 (2002-07-01), Shitara et al.
patent: 97/10354 (1997-03-01), None
patent: 99/25380 (1999-05-01), None
patent: 00/00219 (2000-01-01), None
patent: 00/42074 (2000-07-01), None
patent: 00/67791 (2000-11-01), None
David P. Andrew et al., “C-C Chemokine Receptor 4 Expression Defines a Major Subset of Circulating Nonintestinal Memory T Cells of Both Th1 and Th2 Potential”, The Journal of immunology, 2001, 166:103-111.
Toshio Imai et al., “Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine”, International Immunology, 11(1): 81-88.
Nicholas F. Landolfi et al., “The Integrity of the Ball-and-Socket Joint Between V and C Domains Is Essential for Complete Activity of a Humanized Antibody”, The Journal of Immunology, 2001, 166: 1748-1754.
Xing-Yue He et al., “Humanization and Pharmacokinetics of a Monoclonal Antibody with Specificity for Both E- and P-Selectin”, The Journal of Immunology, 1998, 160:1029-1035.
Paul S. Brown et al., “Anti-Tac-H, a humanized antibody to the interleukin 2 receptor, prolongs primate cardiac allograft survival”, Proc. Natl. Acad. Sci. USA, 1991, 88: 2663-2667.
Man Sung CO et al., “Humanized antibodies for antiviral therapy”, Proc. Natl. Acad. Sci. USA, 1991, 88:2869-2873.
R. P. Junghans et al., “Anti-Tac-H, a humanized Antibody to the Interleukin 2 Receptor with New Features for Immunotherapy in Malignant and Immune Disorders”, Cancer Research, 1990, 50: 1495-1502.
Cary Queen et al., “A humanized antibody that binds to the interleukin 2 receptor”, Proc. Natl. Acad. Sci. USA, 1989, 86: 10029-10033.
Kenneth J. Clemetson et al., “Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets”, Blood, 2000, 96(13): 4046-4054.
Christine A. Power et al., “Molecular Cloning and Functional Expression of a Novel CC Chemokine Receptor cDNA from a Human Basophilic Cell Line”, The Journal of Biological Chemistry, 1995, 270(33): 19495-19500.
Dan Jones et al., “Expression pattern of T-cell-associated chemokine receptors and their chemokines correlates with specific subtypes of T-cell non-Hodgkin lymphoma”, Blood, 2000, 96(2): 685-690.
Barbara M. Mueller et al., “Enhancement of Antibody-Dependent Cytotoxicity with a Chimeric Anti-GD2 Antibody”, The Journal of Immunology, 1990, 144(4): 1382-1386.
Lutz Riechmann et al., “Reshaping human antibodies for therapy”, Nature, 1988, 332: 323-327.
A. van den Berg et al., “High Expression of the CC ChemokineTARCin Reed-Sternberg Cells: A Possible Explanation for the Characteristic T-Cell Infiltrate in Hodgkin's Lymphoma”, American Journal of Pathology, 1999, 154(6): 1685-1691.
Daniele D'Ambrosio et al., “Cutting Edge: Selective Up-Regulation of Chemokine Receptors CCR4 and CCR8 upon Activitation of Polarized Human Type 2 Th Cells”, The Journal of Immunology, 1998, 161: 5111-5115.
Raffaella Bonecchi et al., “Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s”, J. Exp. Med., 1998, 187(1): 129-134.
Byung-S. Youn et al., “Molecular Cloning and Characterization of a cDNA, CHEMR1, Encoding a Chemokine Receptor with a Homology to the Human C-C Chemokine Receptor, CCR-4”, Blood, 1997, 89(12): 4448-4460.
Jose M.R. Frade et al., “The Amino-terminal Domain of the CCR2 Chemokine Receptor Acts as Coreceptor for HIV-1 Infection”, J. Clin. Invest., 1997, 100(3): 497-502.
Syed V.S. Kashmiri et al., “SDR grafting- a new approach to antibody humanization”, Methods, 2005, 36:25-34.
Seth Lederman et al., “A Single Amino Acid Substitution in a Common African Allele of the CD4 Molecule Ablates Binding of the Monoclonal Anitbody, OKT4”, Molecular Immunology, 1991, 28(11): 1171-1181.
Craig Gerard et al., “Chemokine and disease”, Nature Immunology, 2001, 2(2): 108-115.
Man Sung CO. et al., “Humanized Anti-Lewis Y Antibodies: In Vitro Properties and Pharmacokinetics in Rhesus Monkeys”, Cancer Research, 1996, 56:1118-1125.

Affiliated with

Also associated with

Rating

Human CDR-grafted antibody and antibody fragment thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human CDR-grafted antibody and antibody fragment thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human CDR-grafted antibody and antibody fragment thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4225693