Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1993-09-20
1995-08-15
Furman, Keith C.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
435 691, 435 693, 4351723, 435194, 4353201, 530350, 5303871, 536 221, 536 231, 536 232, 536 235, C12N 910, C12N 1500, C12Q 168, C07H 1900
Patent
active
054418801
ABSTRACT:
Two previously undescribed human cdc25 genes, designated cdc25 A and cdc25 B, which have been shown to have an endogenous tyrosine phosphatase activity that can be specifically activated by B-type cyclin, in the complete absence of cdc2.
As a result of the work described herein, new approaches to regulating the cell cycle in eukaryotic cells and, particularly, to regulating the activity of tyrosine specific phosphatases which play a key role in the cell cycle are available. Applicant's invention relates to methods of regulating the cell cycle and, specifically, to regulating activation of cdc2-kinase, through alteration of the activity and/or levels of tyrosine phosphatases, particularly cdc25 phosphatase, and B-type cyclin or through alteration of the interaction of components of MPF, particularly the association of cdc25 with cyclin, cdc2 or the cdc2/cyclin B complex. The present invention also relates to agents or compositions useful in the method of regulating (inhibiting or enhancing) the cell cycle. Such agents or compositions are, for example, inhibitors (such as low molecular weight peptides or compounds, either organic or inorganic) of the catalytic activity of tyrosine specific PTPases (particularly cdc25), blocking agents which interfere with interaction or binding of the tyrosine specific PTPase with cyclin or the cyclin/cdc2 complex, or agents which interfere directly with the catalytic activity of the PTPases.
REFERENCES:
Gautier, J. et al., Cell, 67:197-211 (Oct. 4, 1991).
Dunphy, W. G. and A. Kumagai, Cell, 67:189-196 (Oct. 4, 1991).
Sadhu et al. "Human homolog of fission yeast . . . "PNAS 87, pp. 5139-5143 Jul. 1990.
Lerner "Tapping the immunological . . . "Nature 299, pp. 592-596 14 Oct. 1982.
Nagata et al. "An additional homolog . . . "The New Biolgist 3, pp. 959-968 Oct. 1991.
Galaktionov et al. "Specific activation of cdc25 . . . "Cell 67, pp. 1181-1194 Dec. 20, 1991.
Beach David H.
Galaktionov Konstantin
Cold Spring Harbor Laboratory
DeConti, Jr. Giulio A.
Furman Keith C.
Kim Hyosuk
Vincent Matthew P.
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