Human CD28 specific monoclonal antibodies for...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S387100, C530S388100, C530S388200, C530S388220, C530S388700, C530S388730, C435S326000, C435S332000, C435S334000, C435S343000, C435S343100, C435S343200, C435S346000

Reexamination Certificate

active

06987171

ABSTRACT:
The invention teaches human-compatible monoclonal antibodies which are specific against human CD28 and human T-lymphocytes of several to all sub-groups to activate without occupancy of an antigen receptor of the human T-lymphocytes and thus antigen-non-specifically.

REFERENCES:
patent: 5558864 (1996-09-01), Bendig et al.
patent: 5858358 (1999-01-01), June et al.
Siefken et al. Cell. Immnol. Feb. 1997; 176:59-65.
Tacke et al. Eur. J. Immunol. Jan. 1997; 27:239-247.

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