Human CD154 binding molecules and treatment methods

Details Human CD154 binding molecules and treatment methods Human CD154 binding molecules and treatment methods

2007-01-30

2007-01-30

Gambel, Phillip (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S130100, C424S133100, C424S141100, C424S143100, C424S144100, C424S153100, C424S173100, C530S387100, C530S387300, C530S388100, C530S388200, C530S388220, C530S388700, C530S388730, C530S388750, C536S023100, C536S023500, C536S023530

Reexamination Certificate

active

10221529

ABSTRACT:
A CD154 binding molecule, in particular an antibody to human CD154, especially a human antibody to human CD154 is provided, wherein the CDRs of the heavy chain and light chain have amino acid sequences as defined, for use in the treatment and/or prevention of diseases or disorders wherein CD154 modulation and/or interference with or inhibition of the CD154:CD40 interactions is therapeutically beneficial.

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Kirk et al., “Treatment with Humanized Monoclonal Antibody Against CD154 Prevents Acute Renal Allograft Rejection in Nonhuman Primates”, Nature Medicine, vol. 5, No. 6, pp. 686-693 (1999).
Chambers-Slater et al., “A Humanized Anti-Human CD154 Monoclonal Antibody Blocks CD154-CD40 Mediated Human B Cell Activation”, The FASEB Journal, vol. 13, No. 5, Part 2, p. A988 (1999).

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