Human cathepsin

Details Human cathepsin Human cathepsin

1997-06-26

2000-03-07

Hobbs, Lisa

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4353201, 4352523, 43525411, 435325, 536 232, 536 243, C12N 948, C12N 1500, C12N 120, C07H 2104

Patent

active

060338938

ABSTRACT:
The invention provides a new human cathepsin (LCAP) and polynucleotides which identify and encode LCAP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of LCAP.

REFERENCES:
Huisman, W. et al., "Role of Individual Cathepsins In Lysosomal Protein Digestion As Tested By Specific Inhibitors", Biochimca et Biophysica Acta, 370: 297-307 (1974).
Mizuochi, T. et al., "Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain", Immunol. Lett., 43: 189-193 (1994).
Baldwin, E.T. et al., "Crystal structures of native and inhibited forms of human cathepsin D: Implications for lysosomal targeting and drug design", Proc. Natl. Acad. Sci. USA, 90: 6796-6800 (1993).
Troen, B.R. et al., "Downstream Sequences Mediate Induction of the Mouse Cathepsin L Promoter by Phorbol Esters", Cell Growth Differ., 2: 23-31 (1991).
Keyszer, G.M. et al., "Comparative Analysis Of Cathepsin L, Cathepsin D, And Collagenase Messenger RNA Expression In Synovial Tissues Of Patients With Rheumatoid Arthritis And Osteoarthritis, By In Situ Hybridization", Arthritis Rheum., 38: 976-984 (1995).
Baricos, W.H. et al., "Evidence Suggesting a Role for Cathepsin L in an Experimental Model of Glomerulonephritis", Arch. Biochem. Biophys., 288: 468-472 (1991).
Consonni, R. et al., "Further characterization of platelet-aggregating cysteine proteinase activity in thrombotic thrombocytopenic purpura", Br. J. Hematol., 87: 321-324 (1994).
Chambers, A.F. and A.B. Tuck, "Ras-Responsive Genes and Tumor Metastasis", Crit. Rev. Oncog., 4: 95-114 (1993).
Gal, S. et al., (Direct Submission), GenBank Sequence Database (Accession X12451), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 29714; GI 29715) Mar. 31, 1995.
Gal, S. and M.M. Gottesman, "Isolation and sequence of a cDNA for human pro-(cathepsin L)", Biochem. J., 253: 303-306 (1988) (GI 29714; GI 29715).
Okamura, N. et al., (Direct Submission), GenBank Sequence Database (Accession D37917), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 710655; GI 1468964) Aug. 8, 1994.
Okamura, N. et al., "Direct evidence for the elevated synthesis and secretion of procathepsin L in the distal caput epididymis of boar", Biochimica et Biophysica Acta, 1245: 221-226 (1995) (GI 710655; GI 1468964).
Adams et al. (1995) Initial Assessment of Human Gene Diversity and Expression Patterns Based Upon 83 Million Nucleotides of cDNA Sequence, Nature 377(6547 Suppl.): 3-17.
Adams et al. EST177928 Colon carcinoma (HCC) cell line Homo sapiens cDNA 5'end similar to cathepsin L, EST Accession No. AA307011, release date Apr. 18, 1997.
Hillier et al. zs40d02.s1 Soares NhHMPu S1 Homo sapiens cDNA clone 687651 3' similar to gb:X12451 cathepsin L precursor (human), EST Accession No. AA235364, release date Mar. 3, 1997.
Gay et al. (1985) Molecular Cloning of a Bovine Cathepsin. Biochem. J. 225: 707-712.
Georgiou (1988) Optimizing the Production of Recombinant Proteins in Microorganisms. AIChE. J. 34(8): 1233-1248.

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