Human cartilege gp39-like gene

Details Human cartilege gp39-like gene Human cartilege gp39-like gene

1996-08-09

1998-09-22

Huff, Sheela

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 530300, 530350, 435 691, 4351723, C07H 2104

Patent

active

058115358

ABSTRACT:
HC gp39-L polypeptides and DNA (RNA) encoding such HC gp39-L and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HC gp39-L for the treatment of rheumatoid and osteoarthritis, osteoporosis, artherosclerosis, metastatic cancers, periodontia, chronic renal diseases, etc. Antagonists against such HC gp39-L and their use as a therapeutic to treat rheumatoid and osteoarthritis, osteoporosis, artherosclerosis, metastatic cancers, periodontia, chronic renal diseases, etc. are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HC gp39-L and for detecting altered levels of the polypeptide in a host.

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