Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-06-18
2010-06-15
Ton, Thaian N (Department: 1632)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S455000
Reexamination Certificate
active
07737253
ABSTRACT:
The present invention provides compositions and methods for the culture and maintenance of cancer stem cells. More particularly, the present invention provides the identification of cancer stem cell specific markers and methods of recognizing the same for the detection of tumors, for facilitating the prognosis of a patient with a tumor, and for the treatment of various cancers. The invention also provides antibodies that specifically recognize the disulfide linked Erbb2Δ16 homodimer, an Erbb2Δ16/Erbb3 heterodimer, or post-translational modifications of Erbb2 that are specific to Erbb2 of variant hESCs. In addition, the invention provides a modified defined media useful in the absence of a feeder layer and in the absence of serum or serum replacement, that comprises a basal salt nutrient solution, bFGF, IGF-I, and Activin A, and wherein the composition does not comprise heregulin. The invention further relates to the use of an Erbb2 variant isoform to generate robust cell cultures that are independent of heregulin.
REFERENCES:
patent: 5811098 (1998-09-01), Plowman et al.
patent: 6528060 (2003-03-01), Nicolette
patent: 6632979 (2003-10-01), Erickson et al.
patent: 6984522 (2006-01-01), Clarke et al.
patent: 7060279 (2006-06-01), Laus et al.
patent: 2002/0001587 (2002-01-01), Erickson et al.
Alignment data printed from the SCORE results for PCT/US07/71486, pp. 1-3.
Akiyama et al., 1986, “The Product of the Human c-erbB-2 Gene: A 185-Kilodalton Glycoprotein with Tyrosine Kinase Activity,” Science, 232:1644-46.
Anderson et al., 1993, “High-Density Genetic Map of the BRCA1 Region of Chromosome 17q12-q21,” Genomics, 17:618-623.
Brimble et al., 2004, “Karyotypic Stability, Genotyping, Differentiation, Feeder-Free Maintenance, and Gene Expression Sampling in Three Human Embryonic Stem Cell Lines Derived Prior to Aug. 9, 2001,” Stem Cells Dev., 13(6):585-97.
Brumlik et al., 2003, Poster, Faseb Summer Research Conference, “Growth Factor Receptor Tyrosine Kinases in Mitogenesis, Morphogenesis, & Tumorigenesis, Conference,” Omni-Tucson, Tucson, AZ.
Castiglioni et al., 2006, “Role of Exon-16-Deleted HER2 in Breast Carcinomas,” Endocr. Relat. Cancer, 13(1):221-32.
Coussens et al., 1985, “Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chro . . . ,” Science, 230:1132-1139.
Cowan et al., 2004, “Derivation of Embryonic Stem-Cell Lines from Human Blastocysts,” N. Engl. J. Med., 350 (13):1353-6.
De Placido et al., 1998, “c-erbB2 Expression Predicts Tamoxifen Efficacy in Breast Cancer Patients,” Breast Cancer Res. Treat., 52:55-64.
Di Fiore et al., 1987, “erbB-2 is a Potent Oncogene when Overexpressed in NIH/3T3 Cells,” Science, 237:178-182.
Doherty et al., 1999, “The HER-2 / neu Receptor Tyrosine Kinase Gene Encodes a Secreted Inhibitor,” Proc. Nat. Acad. Sci., 96:10869-10874.
Draper et al., 2004, “Recurrent Gain of Chromosomes 17q and 12 in Cultured Human Embyronic Stem Cells,” Nat. Biotechnol., 22(1):53-4.
Draper et al., 2004, “Culture and Characterization of Human Embryonic Stem Cells,” Stem Cells Dev., 13(4):325-36.
Falls, 2003, “Neurogulins: Functions, Forms, and Signaling Strategies,” Exp. Cell. Res., 284:14-30.
Fukushige et al., 1986, “Localization of a Novel v-erbB-Related Gene, c-erbB-2, on Human Chromosome 17 and its Amplification in a Gastric Cancer Cell Line,” Mol. Cell. Biol., 6:955-958.
Jones et al., 1999, “Binding Specificities and Affinities of egf Domains for ErbB Receptors,” FEBS Lett., 447:227-231.
Kaneko et al., 1987, “Human c-erbB-2 Remains on Chromosome 17 in Band q21 in the 15:17 Translocation Association with Acute Promyelocytic Leukemia,” Jpn. J. Cancer Res., 78:16-19.
Kun et al., 2003, “Classifying the Estrogen Receptor Status of Breast Cancers by Expression Profiles Reveals a Poor Prognosis Subpopulation Exhibiting High Expression of the ERBB2 Receptor,” Hum. Mol. Genet. 12:3245-3258.
Ludwig et al., 2006, “Derivation of Human Embryonic Stem Cells is Defined Conditions,” Nature Biotechnol., 24 (2):185-87.
Maitra et al., 2005, “Genomic Alterations in Cultured Human Embryonic Stem Cells,” Nat. Genet., 37(10):1099-103.
Mehta et al., 1998, “Plasma c-erbB-2 Levels in Breast Cancer Patients: Prognostic Significance in Predicting Response to Chemotherapy,” Oncol., 16:2409-2416.
Menendez et al., 2004, “Inhibition of Fatty Acid Synthase (FAS) Suppresses HER2 / neu (erbB2) Oncogene Overexpression in Cancer Cells,” Proc. Nat. Acad. Sci., 101:10715-10720.
Mitalipova et al., 2005, “Preserving the Genetic Integrity of Human Embryonic Stem Cells,” Nat. Biotechnol. 23 (1):19-20.
Muleris et al., 1997, “Assignment of v-erb-b2 Avian Erythroblastic Leukemia viral Oncogene Homolog 2 (ERBB2) to Human Chromosome Band 17q21.1 by in situ Hybridization,” Cytogenet. Cell Genet., 76:34-35.
Neve et al., 2001, “The Role of Overexpressed HER2 in Transformation,” Ann. Oncol., 12 Suppl 1:S9-13.
Oda et al., 2005, “A Comprehensive Pathway Map of Epidermal Growth Factor Receptor Signaling,” Mol. Sys. Biol., 1:2005.0010. Epub May 25.
Pegram et al., 1997, “The Effect of HER-2 / neu Overexpression on Chemotherapeutic Drug Sensitivity in Human Breast and Ovarian Cancer Cells,” Oncogene, 15:537-547.
Semba et al., 1985, “A v-erbB-Related Protooncogene, c-erbB-2, is Distinct from the c-erbB-1 / Epidermal Growth Factor-Receptor Gene and is Amplified in a Human Salivary Gland Adenocarcinoma,” Proc. Nat. Acad. Sci., 82:6497-6501.
Siegel et al., 1999, “Elevated Expression of Activated Forms of Neu/ErbB-2 and ErbB-3 are Involved in the Induction of Mammary Tumors in Transgenic Mice: Implications for Human Breast Cancer,” EMBO J., 18(8):2149-64.
Toyoda-Ohno et al., 1999, “Members of the ErbB Receptor Tyrosine Kinases are Involved in Germ Cell Development in Fetal Mouse Gonads,” Dev. Biol., 215(2):399-406).
Yarden, 2001, “Biology of HER2 and Its Importance in Breast Cancer,” Oncology, 61 Suppl 2:1-13.
Yu et al., 1988, “Overexpression of ErbB2 Blocks Taxol-Induced Apoptosis by Upregulation of p21Cip1, which Inhibits p34Cdc2 Kinase,” Mol. Cell, 2:581-591.
Yuan et al., 2003, Prot. Exp. Pur., 29:217-222.
Zhou et al., 2003, Dysregulation of Cellular Signaling by HER2
eu in Breast Cancer, Semin. Oncol., 30(5 Suppl 16):38-48.
Qiu et al., 1998, “Requirement of ErbB2 for Signaling by interleukin-6 in Prostate Carcinoma Cells,” Nature 393:83-85.
Slamon et al., 1989, “Studies of the HER-2
eu Proto-Oncogene in Human Breast and Ovarian Cancer,” Science, 244:707-712.
Sperger et al., 2003, “Gene Expression Patterns in Human Embryonic Stem Cells and Human Pluripotent Germ Cell Tumors,” PNAS, 100(23):13350-13355.
Stojkovc et al., 2004, “Derivation, Growth, and Applications of Human Embryonic Stem Cells,” Reproduction, 128:259-267.
Tan et al., 2002, “Phosphorylation on Tyrosine-15 of p34Cdc2 by ErbB2 inhibits p34Cdc2 Activation and is Involved in Resistance to Taxol-Induced Apoptosis,” Mol. Cell, 9:993-1004.
Ulloa-Montoya et al., 2005, “Culture Systems for Pluripotent Stem Cells,” J. Biosci. Bioengen., 100(1)12-27.
Van de Vijver et al., 1988, Neu-Protein Overexpression in Breast Cancer, Association with Comedo-Type Ductal Carcinoma in situ and Limited Prognostic Value in State II Breast Cancer, New Eng. J. Med., 319:1239-1245.
Xie et al., 2000, “Population-Based, Case-Control Study of HER2 Genetic Polymorphism and Breast Cancer Risk,” J. Nat. Cancer Inst., 92:412-417.
Yang-Feng et al., 1985, “The Pronatriodilatin Gene is Located on the Distal Short Arm of Human Chromosome 1 and on Mouse Chromosome 4,” Cytogenet. Cell Genet. 40:784.
Robins Allan J.
Schulz Thomas C.
BresaGen, Inc.
Noble Marcia S
Sutherland & Asbill & Brennan LLP
Ton Thaian N
LandOfFree
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