Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence
Patent
1994-08-01
1996-06-25
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
4 to 5 amino acid residues in defined sequence
530331, 530321, A61K 3804, C07K 500
Patent
active
055300979
ABSTRACT:
This application discloses seven newly synthesized pentapeptide amides and our tetrapeptide amides. The synthesis utilized both naturally occurring and modified amino acids; the modified amino acids are constituents of the well known dolastatin 10 and dolastatin 15 which are structurally distinct peptides with excellent antineoplastic activity. These peptides were constructed by introducing a peptide bond between selected amino acids and modified amino acids and coupling the resulting di- and tri-peptides to obtain peptides having a high anticancer activity against a series of human cancer cell lines. ##STR1##
REFERENCES:
patent: 4816444 (1989-03-01), Pettit
patent: 5017691 (1991-05-01), Lee
patent: 5410024 (1995-04-01), Pettit et al.
Pettit George R.
Srirangam Jayaram K.
Williams Michael D.
Arizona Board of Regents acting on behalf of Arizona State Unive
Mybeck Richard R.
Mybect II Walter R.
Nucker Christine M.
Prickril Benet
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