Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence
Patent
1994-08-01
1996-04-02
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
4 to 5 amino acid residues in defined sequence
514 17, C07K 500, C07K 700, C07K 1700, A61K 3800
Patent
active
055041914
ABSTRACT:
Herein disclosed are several pentapeptide methyl ester derivatives of dolatin 10, using both naturally occurring and modified amino acids. The selected modified amino acids are constituents of dolastatin 10 which is a structurally distinct peptide with excellent in vitro and in vivo antineoplastic activity. The structures of these compounds are as shown below: ##STR1##
REFERENCES:
Pettit et al J. Org. Chem vol. 59 p. 2935 (1994).
Pettit George R.
Srirangam Jayaram K.
Williams Michael D.
Arizona Board of Regents acting on behalf of Arizona State Unive
Bentley Paula L.
Huff Sheela J.
Mybeck Richard R.
Schain Howard E.
LandOfFree
Human cancer inhibitory pentapeptide methyl esters does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human cancer inhibitory pentapeptide methyl esters, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human cancer inhibitory pentapeptide methyl esters will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2017258