Human cancer inhibitory pentapeptide amides and esters

Details Human cancer inhibitory pentapeptide amides and esters Human cancer inhibitory pentapeptide amides and esters

1994-08-01

1996-05-28

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

530331, A61K 3800, A61K 3804, C07K 500, C07K 7400

Patent

active

055212840

ABSTRACT:
The isolation, elucidation and synthetic replication of novel pentapeptide mides and esters are described. The compounds have the general structure ##STR1## in which R.sub.1 and R.sub.2 are selected as shown below: ##STR2##

REFERENCES:
patent: 4816444 (1989-03-01), Pettit et al.
patent: 5017691 (1991-05-01), Lee et al.
Grantham et al, Science vol. 185 p. 862 (1974).
Harper's Review of Biochemistry, 20th ed. p. 17 (1985).
Pettit et al J. Org. Chem vol. 59 p. 2935 (1994).
Hamada et al Tet. Lett. vol. 32 p. 931 (1991).

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