Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence
Patent
1993-01-21
1995-04-25
Warden, Jill
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
4 to 5 amino acid residues in defined sequence
C07K 700, C07K 706, A61K 3800
Patent
active
054100240
ABSTRACT:
The synthesis of useful peptides presents a promising approach to new theeutic agents. The Dolastatins, a series of linear and cyclic antineoplastic and/or cytostatic peptides isolated from Indian Ocean sea hare Dolabella auricularia represent excellent leads for synthetic modification.
The extraordinary inhibition of cell growth shown by the pentapeptideamides against six major types of human cancer has been presented. The intermediates of these reaction also show anticancer activity against the murine P388 lymphocytic leukemia cell line.
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patent: 4879278 (1989-11-01), Pettit et al.
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patent: 5076973 (1991-12-01), Pettit et al.
patent: 5138036 (1992-08-01), Pettit et al.
Dermer, Biotechnology, vol. 12, Mar. 1994.
Barkoczy Jozsef
Kantoci Darko
Pettit George R.
Arizona Board of Regents acting on behalf of Arizona State Unive
Marshall S. G.
Mybeck Richard R.
Warden Jill
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