Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1992-03-17
1993-02-23
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530350, C07K 700
Patent
active
051891441
ABSTRACT:
Polypeptides are provided which have a calpain inhibitory activity. The polypeptides have an activity like that of natural human calpastatin but are significantly shorter in length than natural human calpastatin. The polypeptides are suited for synthetic manufacture.
REFERENCES:
patent: 5037957 (1991-08-01), Grubb et al.
Asada et al., J. Enzyme Inhibition, 1989, vol. 3, pp. 49-56.
Emori et al., The Jour. of Biolog. Chem., vol. 263, No. 5 Feb. 15, 1988, pp. 2364-2370.
Kawasaki et al., J. Biochem., 106, 274-281 (1989).
Maki et al., J. Biolog. Chem., vol. 264, No. 32 Nov. 15, 1989, pp. 18866-18869.
Uemori et al., Biochemical and Biophysical Research Communications, vol. 166, No. 3 (1990) pp. 1485-1493.
Asada Kiyozo
Endo Masahiro
Kato Ikunoshin
Kimizuka Fusao
Uemori Takashi
Guest Shelly J.
Hill Jr. Robert J.
Takara Shuzo Co. Ltd.
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