Human calcitonin precursor polyprotein structural gene

Details Human calcitonin precursor polyprotein structural gene Human calcitonin precursor polyprotein structural gene

1992-12-08

1994-07-26

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 697, 435 691, 4351723, 514 12, 530307, C12P 2102, C07K 738, A61K 3700

Patent

active

053326644

ABSTRACT:
Production of human calcitonin precursor structural gene, the insertion of this gene in a vector system, the cloning thereof and a process for the production of authentic human calcitonin using recombinant DNA biotechnology.

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Breddam, Klaus et al., "Amidation of Growth Hormone Releasing Factor (1-29) by Serine Carboxypeptidase Catalysed Transpeptidation", Int. J. Peptide Protein Res., 37, 1991, 153-160.
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Gunther Kreil et al., Federation Proceedings, "Biosynthesis of a Secretory Peptide in Honeybee Venom Glands: Intermediates Detected in vivo and in vitro", vol. 36, No. 8, Jul. 1988, 2081-2086.
A. F. Bradbury et al., "Mechanism of C-terminal Amide Formation by Pituitary Enzymes", Nature, vol. 298, pp. 686-688 (1982).
Desplan et al., "Cell Free Translation of mRNA Coding for Human and Murine Calcitonin", FEBS Letters, 117, No. 1, pp. 89-92 (1980).
Goodman et al., "Cell-Free Translation of Messenger RNA Coding for a Precursor of Human Calcitonin", Biochem Biophys Res. Commun, vol. 91, No. 3, pp. 932-938 (1979).
Arama et al., "Characterization of Rat Calcitonin mRNA", Proc. Natl. Acad. Sci., (USA), 77, 4444-4448 (1980).

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