Human breast carcinoma cell line capable of production of a spon

Details Human breast carcinoma cell line capable of production of a spon Human breast carcinoma cell line capable of production of a spon

1994-12-07

1997-12-02

Ketter, James

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

C12N 508

Patent

active

056935331

ABSTRACT:
An adherent, stable, continuous human breast carcinoma cell line (GI-101A) has been produced from an infiltrating ductal breast carcinoma xenograft (GI-101) which has been grown and maintained in athymic mice for the past nine years. The GI-101A cells grow with an average doubling time of about 48 to about 72 hours. The cells display antigenic determinants consistent with those of the human breast tumor xenograft (GI-101) from which it was derived. The cell line, GI-101A, when injected subcutaneously into the subaxial area of athymic animals, such as athymic mice, produces tumors that spontaneously metastasize to distant organ sites, such as the lungs and lymph nodes. The cell line and the tumors that it produces may be used as model systems for study mechanisms responsible for metastatic behavior and for testing for new as well as screening for effective new anti-cancer drug therapies.

REFERENCES:
Hurst et. al 1993 Br. J. Cancer 68:274-276.
Schwartz, M.K. 1994 In. Antigen & Antibody Molecular Engineering in Breast Cancer Diagnosis & Treatment (ed.) R.L. Ceriani pp. 41-53, Plenum Press. N.Y.

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