Human breast carcinoma cell line capable of production of a spon

Details Human breast carcinoma cell line capable of production of a spon Human breast carcinoma cell line capable of production of a spon

1997-10-27

2000-03-14

Hauda, Karen M.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

The nonhuman animal is a model for human disease

800 8, 424 931, A61K 4800

Patent

active

060375205

ABSTRACT:
An adherent, stable, continuous human breast carcinoma cell line (GI-101A) has been produced from an infiltrating ductal breast carcinoma xenograft (GI-101) which has been grown and maintained in athymic mice for the past nine years. The GI-101A cells grow with an average doubling time of about 48 to about 72 hours. The cells display antigenic determinants consistent with those of the human breast tumor xenograft (GI-101) from which it was derived. The cell line, GI-101A, when injected subcutaneously into the subaxial area of athymic animals, such as athymic mice, produces tumors that spontaneously metastasize to distant organ sites, such as the lungs and lymph nodes. The cell line and the tumors that it produces may be used as model systems for study mechanisms responsible for metastatic behavior and for testing for new as well as screening for effective new anti-cancer drug therapies.

REFERENCES:
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Bolton, W.E. et al. (1992) Cytometry 13(2):117-126.
Arai et al. "Cytokines: Coordinators of Immune and Inflammatory Responses," Annu. Rev. Biochem., vol. 59: 783-836, 1990.
Fitch et al. "Differential Regulation of Murine lymphocyte Subsets," Annu. Rev. Immunol., vol. 11: 29-48, 1993.

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