Human brain carboxypeptidase B

Details Human brain carboxypeptidase B Human brain carboxypeptidase B

2006-06-13

2006-06-13

Prouty, Rebecca E. (Department: 1652)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

C435S320100, C435S252300, C435S004000, C435S024000, C435S212000, C536S023200, C530S324000, C530S325000, C530S326000, C530S350000, C530S395000, C530S327000

Reexamination Certificate

active

07060266

ABSTRACT:
A novel carboxypeptidase and the encoding gene thereof were successfully identified by screening a human hippocampus extract using brain-APP-cleaving activity as an index. This protein and its gene are useful in, for example, preventing, treating, examining, and diagnosing Alzheimer's disease, and such.

REFERENCES:
Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D. Isolation, molecular cloning, and partial characterization of a novel caroxypeptidase B from human plasma. J Biol Chem. 1991 Nov. 15, 226(32)):21833-8.
Eaton et al., “Isolation, molecular cloning, and partial characterization of a novel carboxypepidase B from human plasma,”J. Biol. Chem., 266(32):21833-21838 (1991).
Goldstein et al., “Human Mast Cell Carboxypeptidase, Purification and Characterization,”J. Clin. Invest., 83(5):1630-1636 (1989).
Inohara et al., “Two Genes atpC1 and atpC2 for the γ Subunit ofArabidopsis thalianaChlorplast ATP Synthase,”J. Biol. Chem., 266(12):7333-7338 (1991).
Kang et al., “The precursor of Alzheimer's disase amyloid A4 protein resembles a cell-surface receptor,”Nature, 325(6106):733-736 (1987).
Matsumoto et al., “A Novel carboxypeptidase B that processes native β-amyloid precursor protein is present in human hippocampus,”Eur. J. Neuroscience, 12(1)7-238 (2000).
Matsumoto et al., “A human brain proteolytic activity capable of cleaving natural beta-amyloid precursor protein is affected by its substrate glycoconjugates,”Neurosci. Letters, 242(2):109-113 (1998).
Matsumoto et al., “Aberrant proteolysis of the beta-amyloid precursor protein in familial Alzheimer's disease lymphoblastoid cells,”Eur. J. Biochem., 217(1):21-27 (1993).
Matsumoto et al., “Abnormal and deficient processing of beta-amyloid precursor protein in familial Alzheimer's disease lymphoblastoid cells,”Biochem Biophys. Res. Commun., 175(2):361-365 (1991).
Reynolds et al., “Cloning and Characterization of the Novel Gene for Mast Cell Carboxypeptidase A,”J. Clin. Invest., 89(1):273-282 (1992).
Shioi et al., “Chondroitin sulfate proteoglycan form of the Alzheimer's beta-amyloid precursor,”J. Biol. Chem., 267(20):13819-13822 (1992).
Tan et al., “Activation and characterization of procarboxypeptidase B from human plasma,”Biochemistry, 34(17):5811-5816 (1995).
Yamamoto et al., “Isolation of cDNA Encoding a Human Serum Marker for Acute Pancreatitis,”J. Biol. Chem., 267(4):2575-2581 (1992).

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