Human bone marrow endothelial cell line and methods of use there

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435378, 435380, 435373, 435 63, 435 64, G01N 3353, C12N 500

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059255315

ABSTRACT:
The present invention provides immortalized human bone marrow endothelial cells which are useful for the study of tumor metastasis. In particular, the human bone marrow endothelial cell lines provided by the invention provide an in vitro model system for screening compounds for the ability to reduce, prevent, or inhibit the metastasis of cancer cells to bone tissue.

REFERENCES:
Galasko (1981) "Bone Metastases Studied in Experimental Animals," Clin. Orthop. 155:269-285.
Paget (1989) "Distribution of Secondary Growths in Cancer of the Breast," Lancet 1:571-573.
Galasko (1981) "The Anatomy and Pathways of Skeletal Metastases," in Bone Metastasis, Weiss and Gilbert, eds., G. K. Hall, Medical Publishers, pp. 49-63.
Jacobs (1983) "Spread of Prostatic Cancer to Bone," Urology 21:337-344.
Body (1992) "Metastatic Bone Disease: Clinical and Therapeutic Aspects," Bone 13:S57-S62.
Zetter et al. (1992) "The Cellular Basis for Prostate Cancer Metastasis," in Prostate Cancer and Bone Metastasis, J.P. Karr and H. Yamanaka, eds., Plenum Press, New York, pp. 39-43.
Bautista et al. (1990) "Insulin-like Growth Factors I and II are Present in the Skeletal Tissues of Ten Vertebrates," Metabolism 39:96-100.
Hauschka et al. (1986) "Growth Factors in Bone Matrix," J. Biol. Chem. 261:12665-12674.
Littlewood et al. (1991) "The Modulation of the Expression of IL-6 and Its Receptor in Human Osteoblasts in Vitro," Endocrinology 129:1513-1520.
Haq et al. (1992) "Rat Prostate Adenocarcinoma Cells Disseminate to Bone and Adhere Preferentially to Bone Marrow-derived Endothelial Cells," Cancer Res. 52:4613-4619.
Graham et al. (1973) "Transformation of Rat Cells by DNA of Human Adenovirus 5," Virology 54(2):536-539.
Pitot (1978) "The Language of Oncology," in Fundamentals of Oncology, marcel Dekker (Ed.), New York, pp. 15-28.
Rafii, et al. (1994) "Isolation and Characterization of Human Bone Marrow Microvascular Endothelial Cells: Hematopoietic Progenitor Cell Adhesion," Blood 84:10-19.
Schweitzer et al. (1995) "Isolation and culture of human bone marrow endothelial cells," Exp. Hematology 24:41-48.
Masek et al. (1994) "Isolation and culture of endothelial cells from huam bone marrow," Br. J. Haematol. 88:855-865.
Albelda et al. (1990) "Integrins and other cell adhesion molecules," FASEB J. 4:2868-2880.
Hynes (1992) "Integrins: Versatility, Modulation and Signaling in Cell Adhesion," Cell 69:11-25.
Oka et al. (1993) "Expression of E-Cadherin Cell Adhesion Molecules in Human Breast Cancer Tissues and its Relationship to Metastasis," Cancer Res. 53:1696-1701.
Honn et al. (1992) "Adhesion molecules and tumor cell interaction with endothelium and subendothelial matrix," Cancer and Metastasis Rev. 11:353-375.
Gamble et al. (1985) "Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor," Proc. Nat. Acad. Sci. USA 82:8667-8671.
Sugama et al. (1992) "Thrombin-induced Expression of Endothelial P-Selectin and Intracellular Adhesion Molecule-1: A Mechanism for Stabilizing Neutrophil Adhesion," J. Cell. Bio. 119(4) 935-944.
Jackson et al. (1990) "Binding of human endothelium to Ulex europaeus I-coated Dynabeads: application to the isolation of microvascular endothelium," J. Cell Science 96:257-262.
Voyta et al. (1984) "Identification and Isolation of Endothelial Cells Based on Their Increased Uptake of Acetylated-Low Density Lipoprotein," J. Cell Bio. 99(6):2034-2040.
Montesano et al. (1983) "In Vitro Rapid Organization of Endothelial Cells into Capillary-like Networks Is Promoted by Collagen Matrices," J. Cell. Bio. 97:1648-1652.
Weibel et al. (1964) "New Cytoplasmic Components in Arterial Endothelia," J. Cell. Bio. 23:101-112.
Wagner et al. (1993) "The Weibel-Palade Body: the Storage Granule for von Willebrand Factor and P-selectin," Thromb. and Haemost. 70(1):105-110.
Piechocki et al. (1992) "TPA-induced differentiation of rat aortic endothelial cells is substrate-specific and receptor mediated," Exp. Sci. 61:152-157.
Inohara and Raz (1995) "Functional Evidence that Cell Surface Galectin-3 Mediates Homotypic Cell Adhesion," Cancer Res. 55:3267-3271.
Matsuno et al. (1994) "Inhibition of Integrin Function by a Cyclic RGD-Containing Peptide Prevents Neointima Formation," Circulation 90:2203-2206.
Almeida-Porada et al. (1996) "Isolation, characterization, and biologic features of bone marrow endothelial cells," J. Lab. Clin. Med. 128(4):399-407.
Schweitzer et al. (1997) "Characterization of a Newly Established Human Bone Marrow Endothelial Cell Line: Distinct Adhesive Properties for Hematopoietic Progenitors Compared with Human Umbilical Vein Endothelial Cells," Lab. Invest. 76(1)-25-36.
haq et al, Cancer Res. 52, 4613-4619, 1992.
Lotan et al, Glycoconjugate Journal, 11, 462-468, 1994.

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