Human bikunin

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C435S320100, C435S440000, C435S195000, C435S069100, C514S008100, C514S04400A

Reexamination Certificate

active

07019123

ABSTRACT:
The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental bikunin, serine protease inhibitor domains, and fragments thereof

REFERENCES:
patent: 5106833 (1992-04-01), Bronze, Jr. et al.
patent: 5223482 (1993-06-01), Schilling, Jr. et al.
patent: 5312736 (1994-05-01), Rasmussen et al.
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5407915 (1995-04-01), Fritz et al.
patent: 5436153 (1995-07-01), Sprecher et al.
patent: 5441931 (1995-08-01), Sprecher et al.
patent: 5541288 (1996-07-01), Nakano et al.
patent: 5576294 (1996-11-01), Norris et al.
patent: 5663143 (1997-09-01), Ley et al.
patent: 5677146 (1997-10-01), Sprecher et al.
patent: 5728674 (1998-03-01), Sprecher et al.
patent: 5731412 (1998-03-01), Shimomura et al.
patent: 5736364 (1998-04-01), Kelley et al.
patent: 5747449 (1998-05-01), Lasters et al.
patent: 5786328 (1998-07-01), Dennis et al.
patent: 5795865 (1998-08-01), Markland et al.
patent: 5834244 (1998-11-01), Dennis et al.
patent: 5854396 (1998-12-01), Shimomura et al.
patent: 0 563 389 (1993-10-01), None
patent: 0 439 442 (1996-03-01), None
patent: 0 758 682 (1997-02-01), None
patent: WO 92/15605 (1992-09-01), None
patent: WO 93/14120 (1993-07-01), None
patent: WO 95/18830 (1995-07-01), None
patent: WO 96/35788 (1996-11-01), None
patent: WO 96/03503 (1997-02-01), None
patent: WO 97/33996 (1997-09-01), None
patent: WO 98/33920 (1998-08-01), None
App, E.M., King, M., Helfesrieder, R., Kohler, D., and Matthys, H. (1990) Acute and long-term amiloride inhalation in cystic fibrosis lung disease. A rational approach to cystic fibrosis therapy.American Review of Respiratory Disease141, 605-612.
Chraibi, A., Vallet, V., Firsov, D., Hess, S.K., and Horisberger, J.D. Protease modulation of the activity of the epithelial sodium channel expressed in xenopus oocytes.Journal of General Physiology111(1): 127-138, 1998.
Delaria, K.A., Muller, D.K., Marlor, C.W., Brown, J.E., Das, R.C., Roczniak, S.O. and Tamburini, P.P. Characterization of placental bikunin, a novel serine protease inhibitor.Journal of Biological Chemistry272(18):12209-12214, 1997.
Denda, K. Genbank accession No. AB006534. “Homo sapiens mRNA for hepatocyte growth factor activator inhibitor type 2, complete cds.” Mar. 4, 1998.
Dietrich, W. et al. (1989) Thorac. Cardiovasc. Surg. 37:92-98.
Hillier, L. et al. EMBL/Genbank accession No. N39798. “The WashU-Merck EST Project.” Jan. 26, 1996.
Hillier, L. et al. EMBL/Genbank accession No. R35464. “The WashU-Merck EST Project.” May 4, 1995.
Hillier, L. et al. EMBL/Genbank accession No. R74593. “The WashU-Merck EST Project.” Jun. 9, 1995.
Kawaguchi, T., Qin, L., Shimomura, T., Kondo, J., Matsumoto, K. Denda, K., and Kitamura, N. (1997) “Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a kunitz-type serine proteaase inhibitor” J. Biol. Chem. 272:27558-27564.
Lindberg, S., and Olsson, H., 1991 “Tissue Kallikrein Stimulates Mucociliary Activity in the Rabbit Maxillary Sinus,” Acta Oto-Laryngologica, 111, (6) pp. 1126-1132.
Marlor, C.W., Delaria, K.A., Davis, G., Muller, D.K., Greve, J.M., and Tamburini, P.P. Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two kunitz domains.Journal of Biological Chemistry272(18):12202-12208, 1997.
Mathews, L.W., Spector, S., Lemm, J., and Potter, J.L. Studies on Pulmonary secretions. I. The Overall Chemical Composition of Pulmonary Secretions from Patients with Cystic Fibrosis, Bronchiectasis, and Laryngectomy,American Review of Respiratory Disease88:199-204, 1963.
McAulay, A.E., Crossley, J., Place G.A. and Poll, C.T. Effect of UTP on ion transport in tertiary cultures of human bronchial epithelial (HBE) cells.Pediatric PulmonologyS 17, Abs 141, 1998.
Miyazawa, K. et al. (1996) “Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator” J. Biol. Chem. 271:3615-2618.
Newton, B.B. and Hall, R.L., Mucociliary clearance in the guinea-pig is increased by ouabain (i.v.) and by hypertonic saline (14.4%) aerosol. inCilia, Mucus and Mucociliary Interactions. Ed. Baum, G.L., Priel, Z., Roth, Y., Liron, N., Ostfeld, E., Marcel Dekker. New York. 1998.
Newton, B.B., Poll. C.T. and Hall, R.L. Inhalation of amiloride increases tracheal mucus velocity and decreases tracheal potential difference in the guinea-pig. PediatricPulmonologyS17 Abs. 364, 1998.
O'Riordan, T.G., Mao, Y.M., Otero, R., Lopez, J., Sabater, J.R., and Abraham, W.M. Budesonide affects allergic mucociliary dysfunction.Journal of Applied Physiology85(3):1086-1091, 1998.
O'Riordan, T.G., Otero, R., Mao, Y.M., Lauredo, I., and Abraham, W.M. Elastase contributes to antigen-induced mucociliary dysfunction in ovine airways.American Journal of Respiratory&Critical Care Medicine97(5):1522-1528, 1997.
Potter, J.L., Matthews, L.W., Spector, S., and Lemm, J. Studies on pulmonary secretions. II. Osmolality and the ionic environment of pulmonary secretions from patients with cystic fibrosis, bronchiectasis, and laryngectomy.American Review of Respiratory Disease67(I):83-87, 1967.
Rasche, Von B., Marcic, I., and Ulmer, W.T., 1975 “Uber die Wirkung des Proteaseinhibitors Aprotinin auf die Lungenfunktion sowie die inhibitorische Aktivität des Sputums bei Patientin mit chronisch-obstruktiver Bronchitis” Arzneimittel-Forschung (Drug Res.) 25, Nr.(1) 110-116.
Robinson, et al., 1997. “Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis,” pp. 900.
Robinson, M., Hemming, A.L., Regnis, J.A., Wong, A.G., Bailey, D.L., Bautovich, G.J., King, M., and Bye, P.T.P. Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis.Thorax52(10):900-903, 1997.
Schmidt, O.P., 1977, “Medikamentöse Therapie bronchosekretorischer Störungen” Medizinische Klinik. 72 (5), 145-160.
Shimomura, T. et al. (1997) “Hepatocyte growth factor activator inhibitor, a novel kunitz-type serine protease inhibitor” J. Biol. Chem. 272:6370-6376.
Tomkiewicz, R.P., App, E.M., Zayas, J.G., Ramirez, O., Church, N., Boucher, R.C., Knowles, M.R., and King, M. Amiloride inhalation therapy in cystic fibrosis. Influence on ion content, hydration, and rheology of sputum.American Review of Respiratory Disease148(4 Pt 1):1002-1007, 1993.
Vallet, V., Chraibi, A., Gaeggeler, H.P., Horisberger, J.D., and Rossier, B.C. An epithelial serine protease activates the amiloride-sensitive sodium channel.Nature389(6651):607-610, 1997.
Wills, P.J., Garcia Suarez, M.J., Rutman, A., Wilson, R., and Cole, P.J. The ciliary transportability of sputum is slow on the mucus-depleted bovine trachea.American Journal of Respiratory&Critical Care Medicine151(4):1255-1258, 1995.
Wills, P.J., Hall, R.L., Chan, W.M., and Cole, P.J. Sodium chloride increases the ciliary transportability of cystic fibrosis and bronchiectasis sputum on the mucus-depleted bovine trachea.Journal of Clinical Investigation97(11):9-13, 1997.
WOJTA et al. (1994) “Hepatocyte growth factor stimulates expression of plasminogen activator inhibitor type 1 and tissue factor in HepG2 cells” Blood 84:151-157 (Abstract).
Gribben et al. (1990), “Development of antibodies to unprotected glycosylation sites on recombinant human GM-CSF”, The Lancet 335:434-437.
Hotchkiss et al. (1988), “The Influence of Carbohydrate Structure on the Clearance of Recombinant Tissue-Type Plasminogen Activator”, Thrombosis and Harmostasis 60 (2):255-261.
Petersen et al. (1996), “Inhibitory properties of separate recombinant Kunitz-type-protease-inhibitor domains from tissue-factor-pathway inhibitor”, Eur. J. Biochem. 235:310-316.
Hochstrasser et al. (1981), “Kunitz-Type Proteinase Inhibitor Derived by Limited Proteolysis of the Inter-T

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