Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1993-02-26
1995-05-30
Lacey, David L.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241421, 4241741, 43524026, 5303871, 5303877, 5303879, 53038815, 5303888, A61K 39395, C12N 522, C07K 1618, C07K 1630
Patent
active
054199042
ABSTRACT:
A human B-lymphoblastoid cell line which is identified as L612. The L612 cell line is an Epstein-Barr virus transformed cell line which secretes a human monoclonal antibody (L612) which is reactive with glycoconjugates having an epitope of terminal NeuAc .alpha.2-3 Galactose residue such as GM3 and GM4 present on a variety of human tumor tissues. The L612 antibody is useful in treating patients with the epitope containing tumors and is also useful in raising anti-id antibodies for use as surrogate antigens and diagnostic reagents.
REFERENCES:
patent: 4699880 (1987-10-01), Goldstein
patent: 5208146 (1993-05-01), Irie
Matsuki, T., et al., Proc. Ann Meeting Am Assoc Cancer Res, 29:A1694, 1988.
Hellstrom, I et al., Accomplishments in Cancer Res., pp. 216-240, 1984.
Morrison, S. L., et al, PNAS, 81:6851-6855, Nov. 1984.
Harris, W. J. et al., TIBTECH, 11:42-44, Feb. 1993.
Waldmann, T. A., Science, 252:1657-1662, Jun. 1991.
Furukawa, et al., J. Biol Chem 263(34):18507-18512, 1988.
Lacey David L.
Loring Susan A.
The Regents of the University of California
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