Human ATP binding-cassette transport protein

Details Human ATP binding-cassette transport protein Human ATP binding-cassette transport protein

1998-11-18

2000-06-27

Carlson, Karen Cochrane

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530300, C07K 1400

Patent

active

06080842&

ABSTRACT:
The invention provides a human ATP-binding cassette transport protein (ABCtxH) and polynucleotides which identify and encode ABCtxH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of ABCtxH.

REFERENCES:
Higgins, C.F., "ABC Tranporters: From Microorganisms to Man", Annu. Rev. Cell Biol., 8: 67-113 (1992).
Gottesman, M.M. et al., "Biochemistry of Multidrug Resistance Mediated by the Multidrug Transporter", Annu. Rev. Biochem., 62: 385-427 (1993).
Ruetz, S. et al., "Phosphatidylcholine Translocase: A Physiological Role for the mrd2 Gene", Cell, 77: 1071-1081 (1994).
Welsh, M.J. et al., "Molecular Mechanisms of CFTR Chloride Channel Dysfunction in Cystic Fibrosis", Cell, 73: 1251-1254 (1993).
Androlewicz, M.J. et al., "Characteristics of peptide and major histocompatibility complex class I/.beta..sub.2 -microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2)", Proc. Natl. Acad. Sci. USA, 91: 12716-12720 (1994).
Buchler, M. et al., "cDNA Cloning of the Hepatocyte Canalicular Isoform of the Multidrug Resistance Protein, cMrp, Reveals a Novel Conjugate Export Pump Deficient in Hyperbilirubinemic Mutant Rats", J. Biol. Chem., 271: 15091-15098 (1996).
Michaelis, S., "STE6, the yeast a-factor transporter", Semin. Cell Biol., 4: 17-27 (1993).
Savary, S. et al., "Isolation and Chromosomal Mapping of a Novel ATP-Binding Cassette Transporter Conserved in Mouse and Human", Genomics, 41: 275-278 (1997) (GI 1167982).
Savary, S. et al., (Direct Submission), GenBank Sequence Database (Accession 1167982), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1167982).
Savary, S. et al., (Direct Submission), GenBank Sequence Database (Accession U43892), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1167982).
Leighton, J. et al., (Direct Submission), GenBank Sequence Database (Accession 575393), National Center Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 575393).
Leighton, J. et al., (Direct Submission), GenBank Sequence Database (Accession X82612), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 575393).
Leighton, J. et al., "An ABC transporter in the mitrochondrial inner membrane is required for normal growth of yeast", EMBO J., 14: 188-195 (1995) (GI 575393).

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