Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2008-07-22
2008-07-22
Wehbé, Anne Marie (Department: 1633)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S013000, C800S004000, C800S006000
Reexamination Certificate
active
07402729
ABSTRACT:
The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
REFERENCES:
patent: 4959317 (1990-09-01), Sauer
patent: 5270201 (1993-12-01), Richards et al.
patent: 5543319 (1996-08-01), Fournier et al.
patent: 5614396 (1997-03-01), Bradley et al.
patent: 6025155 (2000-02-01), Hadlaczky et al.
patent: 6395487 (2002-05-01), Bradley et al.
patent: 6461818 (2002-10-01), Bradley et al.
patent: 6632976 (2003-10-01), Tomizuka et al.
patent: 7041870 (2006-05-01), Tomizuka et al.
patent: 0 773 288 (1997-05-01), None
patent: 0 843 961 (1998-05-01), None
patent: 0 972 445 (2000-01-01), None
patent: 1 106 061 (2001-06-01), None
patent: 2001-231403 (2001-08-01), None
patent: 2001-231403 (2001-08-01), None
patent: WO 89/09219 (1989-10-01), None
patent: WO 91/19796 (1991-12-01), None
patent: WO 95/32297 (1995-11-01), None
patent: WO 97/49804 (1997-12-01), None
patent: WO 98/46733 (1998-12-01), None
patent: WO 98/54348 (1998-12-01), None
patent: WO 00/10383 (2000-03-01), None
Nicholson et al, Journal of Immunology 163:6898-6906, 1999.
Kazuma Tomizuka et al., “Functional expression and germline transmission of a human chromosome fragment in chimaeric mice”, Nature Genetics, vol. 16, p. 133-143 (1997).
E.S. Dieken et al., “Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids”, Nature Genetics, vol. 12, p. 174-182 (1996).
A.J.H. Smith et al., “A site-directed chromosomal translocatin induced in embryonic stem cells by Cre-IoxP recombination” Nature Genetics, vol. 9, pp. 376-385 (1995).
I. Wilmut et al., “Viable offspring derived from fetal and adult mammalian cells”, Nature, vol. 385, p. 810 (1997).
R. Ramiriz-Solis et al., “Chromosome engineering in mice”, Nature, vol. 378, pp. 720-724 (1995).
W. Mills et al, “Generation of an ˜2.4 Mb human X centromere-based minichromosome by targeted telomere-associated chromosome fragmentation in DT40”, Human Molecular Genetics, vol. 8, No. 5, p. 751-761 (1999).
C.J. Farr et al., “Generation of a human X-derived minichromosome using telomere-associated chromosome fragmentation”, The EMBO Journal, vol. 14, No. 21, pp. 5444-5454 (1995).
M. H. Shen et al., “Human mini-chromosomes in mouse embryonal stem cells”, Human Molecular Genetics, vol. 6, No. 8, pp. 1375-1382, (1997).
W. Brown et al., “Mammalian artificial chromosomes”, Genetics of disease, pp. 281-288.
M. Qin et al., “Cre recombinase-mediated site-specific recombination between plant chromosomes”, Proc. Natl. Acad. Sci. USA, vol. 91, p. 1706-1710 (1994).
M. Koi et al., “Tumor Cell Growth Arrest Caused by Subchromosomal Transferable DNA Fragments fom Chromosome 11”, Science, vol. 260 (1993).
A.E. Schnieke et al., Human Factor IX Transgenic Sheep Produced by Transfer of Nuclei from Transfected Fetal Fibroblasts, Science, vol. 278 (1997).
J.B. Cibelli et al., “Cloned Transgenic Calves Produced from Nonquiescent Fetal Fibroblasts”, Science, vol. 280 (1998).
Y. Kuroiwa et al., “Efficient modification of a human chromosome by telomere-directed truncation in high homologous recombinant-proficieint chicken DT40 cells”, Nucleic Acids Research, vol. 26, No. 14, pp. 3447-3448 (1998).
B. Grimes et al., “Engineering mammalian chromosomes”, Human Molecular Genetics, vol. 7, No. 10, Review, p. 1635-1640 (1998).
M. Brüggemann et al., “Production of human antibody repertoires in transgenic mice”, Current Opinion in Biotechnology, 8 pp. 455-458 (1997).
M. Taniguchi et al., “Efficient production of Cre-mediated site-directed recombinants through the utilization of the puromycin resistance gene, pac: a transient gene-integration marker for ES cells”, Nucleic Acids Research, vol. 26, No. 2, pp. 679-680 (1998).
J.C. Vasquez et al., “Factors for affecting the efficiency of introducing precise genetic changes in ES cells by homologous recombination: tag-and-exchange versus the Cre-loxp system”, Transgenic Research, vol. 7, pp. 181-193 (1998).
S. Gagneten et al., “Brief expression of a GFP cre fusion gene in embryonic stem cells allows rapid retrieval of site-specific genomic deletions”, Nucleic Acids Research, vol. 25, No. 16, pp. 3326-3331 (1997).
N.P. Davies et al., “Creation of Mice Expressing Human Antibody Light Chains by Introduction of a Yeast Artificial Chromosome Containing the Core Region of the Human Immunoglobulin κ Locus”, Bio/Technolgoy, vol. 11, pp. 911-914 (1993).
M.J. Mendez et al., “Analysis of the Structural Integrity of YACs Comprising Human Immunoglobulin Genes in Yeast and in Embryonic Stem Cells”, Genomics, vol. 26, pp. 294-307 (1995).
H. Cooke, “Non-programmed and Engineered Chromosome Breakage”, Cold Spring Harbor Monograph Sereis; Telomeres, pp. 219-245 (1995).
R. Heller et al., “Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage”, Proc. Natl. Acad. Sci. USA, vol. 93, pp. 7125-7130 (1996).
K.A. Henning et al., “[7] Techniques and Applications of Microcell-Mediated Chromosome Transfer to Mammalian Cells”, Methods in Molecular Genetics, vol. 1, Gene and Chromosome Analysis, Part A, pp. 134-150 (1993).
W.M. Moreadith et al., “Gene targeting in embryonic stem cells: the new physiology and metabolism”, J. Mol. Med. , 75, pp. 208-216 (1997).
M.F. Pera et al., “Human embryonic stem cells”, Journal of Cell Science, 113, pp. 5-10 (2000).
K. Tomizuka et al., “Functional expression and germline transmission of a human chromosome fragment in chimaeric mice”, Nature Genetics, vol. 16, pp. 133-143, (1997).
H-H. Gerdes et al., “Green fluorescent protein: applications in cell biology”, FEBS Letters, 389, pp. 44-47 (1996).
International Search Report.
Supplementary Partial European Search Report of EP 02 76 9569.
Shinohara Tokuyuki et al., “Stability of Transferred Human Chromosome Fragments in Cultured Cells and in Mice”, Chromosome Research, vol. 8, No. 8, 2000, pp. 713-725.
K. Tomizuka et al., “Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and k loci and expression of fully human antibodies”, Proceedings of the National Academy of Sciences of USA, National Academy of Science, Washington, US, vol. 97, No. 2, Jan. 18, 2000, pp. 722-727.
Shigeru Araga et al., “Production of monoclonal antibodies (mAb) against human alpha-acetylcholine receptor using KM mice(reg)”, FASEB Journal, vol. 16, No. 5, Mar. 22, 2002, p. A1218.
K. Tomizuka et al., “Creation of Mice Producing Human Antibodies by Using Chromosome Vectors”, Gekkan Soshiki Baiyo Kogaku—Tissue Culture Engineering, NYU Saiensusha, Tokyo, Japan, vol. 24, No. 14, 1998, p. 1.
Y. Kuroiwa et al., “Manipulation of Human Minichromosomes to Carry Greater than Megabase Sized Chromosome Inserts”, Nature Biotechnology, Nature Publishing US, vol. 18, Oct. 2000, pp. 1086-1090.
Supplementary European Search Report of EP 02 76 9569.
Isao Ishida et al., “Pro
Ishida Isao
Kuroiwa Yoshimi
Tomizuka Kazuma
Yoshida Hitoshi
Baker & Botts LLP
Kirin Pharma Kabushiki Kaisha
Wehbe Anne Marie
LandOfFree
Human artificial chromosome containing human antibody... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human artificial chromosome containing human antibody..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human artificial chromosome containing human antibody... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2798172