Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-04-09
1995-05-30
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530395, 435 692, 4351723, 930250, A61K 3817, C07K 1481, C07K 14435, C12N 1515
Patent
active
054202523
ABSTRACT:
A novel human antithrombin III (AT III) mutant having a high antithrombin activity in the absence of heparin and effective in the treatment of thrombotic disorders as an anticoagulant, which is obtained by mutating amino acids at the reactive site and the heparin binding site of human AT III into another amino acids with the use of the recombinant DNA technology with the use of a DNA coding for AT III as a template. The invention also relates to a method for mass producing the above-described mutant by incubating a host transformed by an expression vector having the cDNA of the mutant inserted therein.
Kato Hiroyuki
Mizui Yoshiharu
Nagaoka Naoko
Seto Toshio
Suzuki Noboru
Eisai Co. Ltd.
Jacobson Dian C.
Wax Robert A.
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