Human antibody molecules for IL-13

Details Human antibody molecules for IL-13 Human antibody molecules for IL-13

2004-07-15

2010-11-09

Skelding, Zachary (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S145100

Reexamination Certificate

active

07829090

ABSTRACT:
Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralise IL-13 activity. Methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, including asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.

REFERENCES:
patent: 5859205 (1999-01-01), Adair et al.
patent: 5959085 (1999-09-01), Garrone et al.
patent: 5969108 (1999-10-01), McCafferty et al.
patent: 6811780 (2004-11-01), Furfine et al.
patent: 2003/0235555 (2003-12-01), Shealey et al.
patent: 2004/0234499 (2004-11-01), Shealey et al.
patent: 2005/0065327 (2005-03-01), Monk et al.
patent: WO 94/04680 (1994-03-01), None
patent: WO 00/36103 (2000-06-01), None
patent: WO 00/64944 (2000-11-01), None
patent: WO 00/66631 (2000-11-01), None
patent: WO 01/62933 (2001-08-01), None
patent: WO 03/035847 (2003-05-01), None
patent: WO 03/086451 (2003-10-01), None
patent: WO 2005/062967 (2005-07-01), None
patent: WO 2006/003407 (2006-01-01), None
patent: WO 2006/055638 (2006-05-01), None
Janeway et al., Immunobiology, 5th Ed., Garland Science, pp. 94-105 (2001).
Holt et al., Trends Biotechnol. Nov. 2003;21(11):484-90.
Brown et al., J Immunol. May 1, 1996;156(9):3285-91.
Van den Beucken et al., J Mol Biol. Jul. 13, 2001;310(3):591-601.
Blease, K., et al., “Therapeutic Effect of IL-13 Immunoneutralization During Chronic Experimental Fungal Asthma,” The Journal of Immunology, vol. 166, pp. 5219-5224 (2001).
Catalog No. MAB213—“Monoclonal Anti-human IL-13 Antibody,” R & D Systems (Oct. 14, 2002).
Catalog No. MAB2131—“Monoclonal Anti-human IL-13 Antibody,” R & D Systems (Nov. 3, 2003).
Catalog No. MAB413—“Monoclonal Anti-mouse IL-13 Antibody,” R & D Systems (Dec. 3, 2004).
Heinzmann, A., et al., “Genetic Variants of IL-13 Signalling and Human Asthma and Atopy,” Human Molecular Genetics, vol. 9, No. 4, pp. 549-559 (2000).
Kuperman, D., et al., “Direct Effects of Interleukin-13 on Epithelial Cells Cause Airway Hyperreactivity and Mucus Overproduction in Asthma,” Nature Medicine, vol. 8, No. 8, pp. 885-889 (2002).
Mendez, J., et al., “Functional Transplant of Megabase Human Immunoglobulin Loci Recapitulates Human Antibody Response in Mice,” Nature Genetics, vol. 15, No. 2, pp. 146-156 (1997).
PCT International Search Report of PCT/GB2004/003059 dated Mar. 15, 2005.
Skinnider, B., et al., “Interleukin 13 and Interleukin 13 Receptor are Frequently Expressed by Hodgkin and Reed-Sternberg Cells of Hodgkin Lymphoma,” Blood, vol. 97, No. pp. 250-255 (2001).
Wills-Karp, M., et al., “Interleukin-13: Central Mediator of Allergic Asthma,” Science, vol. 282, pp. 2258-2260 (1998).
Zhu, Z., et al., “Pulmonary Expression of Interleukin-13 Causes Inflammation, Mucus Hypersecretion, Subepithelial Fibrosis, Physiologic Abnormalities, and Eotaxin Production,” vol. 103, No. 6, pp. 779-788 (1999).
Combined Search and Examination Report Under Sections 17 and 18(3), The UK Patent Office, Patents Act 1977, 4 pages (2004).
Grunig et al., “Requirement for IL-13 independently of IL-4 in experimental asthma,” Science, vol. 282, pp. 2261-2263 (1998).
Huang et al., “IL-13 Expression at the sites of allergen challenge in patients with asthma,” Journal of Immunology, vol. 155, pp. 2688-2694 (1995).
Minty et al., “Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses,” Nature, vol. 362, pp. 248-250 (1993).
Punnonen et al., “The relative contribution of IL-4 and IL-13 to human IgE synthesis induced by activated CD4+ or CD3+ T cells,” Journal of Allergy and Clinical Immunology, vol. 100, No. 6, Part 1, pp. 792-801 (1997).
Robinson et al., “Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma,” The New England Journal of Medicine, vol. 326, No. 5, pp. 298-304 (1992).
Stahl et al., “Cytokine Traps: Heteromeric receptor based protein therapeutics that function as high affinity blockers of cytokine action,” FASEB Journal, vol. 13, No. 7, A1585, (1999).
Harlow et al., “Antibodies A Laboratory Manual”, Cold Spring Harbor Press, (1988), 72-77 .
Heinrichs et al., “Universal cloning and direct sequencing of rearranged antibody V genes using C region primers, biotin-captured cDNA and one-side PCR”, Journal of Immunological Methods 178 (1995), 241-51.
Madhankumar et al., “Alanine-scanning Mutagenesis of a-Helix D Segment of Interleukin-13 Reveals New Functionally Important Residues of the Cytokine”, J Biol Chem. Nov. 8, 2002;277(45):43194-205. Epub Aug. 19, 2002.
Makitalo et al, “ELISpot and ELISA analysis of spontaneous, mitogen-Induced and antigen-specific cytokine production in cynomolgus and rhesus macaques”, Journal of Immunological Methods, vol. 270, Issue 1, Dec. 1, 2002, 85-97.
Monk et al., U.S. Appl. No. 10/564,647.
Monk et al., U.S. Appl. No. 11/821,880.
Padlan E., “Anatomy of the Antibody Molecule”, Molecular Immunology, Feb. 1994;31(3):169-217.
Portolano et al., “Lack of Promiscuity in Autoantigen-Specific H and L Chain Combinations as Revealed by Human H and L Chain “Roulette””, J Immunol. Feb. 1, 1993; 150(3):880-7.
Vajdos et al., “Comprehensive Functional Maps of the Antigen-binding Site of an Anti-ErbB2 Antibody Obtained with Shortgun Scanning Mutagenesis”, J Mol Biol. Jul. 5, 2002;320(2):415-28.

Affiliated with

Also associated with

Rating

Human antibody molecules for IL-13 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human antibody molecules for IL-13, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human antibody molecules for IL-13 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4246523