Human antibodies to human IL-6 receptor

Details Human antibodies to human IL-6 receptor Human antibodies to human IL-6 receptor

2009-07-13

2011-10-25

Mertz, Prema (Department: 1646)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C530S387900, C530S388220

Reexamination Certificate

active

08043617

ABSTRACT:
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KDof about 500 pM or less and blocks IL-6 activity with an IC50of 200 pM or less. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.

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