Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2011-04-05
2011-04-05
Yu, Misook (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C536S023100
Reexamination Certificate
active
07919593
ABSTRACT:
An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDll4) and blocks hDll4 binding to a Notch receptor. The human anti-hDll4 antibody or antibody fragment binds hDll4 with an affinity of ≦500 pM, as measured by surface plasmon resonance.
REFERENCES:
patent: 5849869 (1998-12-01), Artavanis-Tsakonas et al.
patent: 6121045 (2000-09-01), McCarthy et al.
patent: 6262025 (2001-07-01), Ish-Horowicz et al.
patent: 6664098 (2003-12-01), Sakano
patent: 6783956 (2004-08-01), Ish-Horowicz et al.
patent: 7022499 (2006-04-01), Sakano
patent: 2003/0180784 (2003-09-01), McCarthy et al.
patent: 2005/0261477 (2005-11-01), Champion et al.
patent: 2006/0134121 (2006-06-01), Thurston et al.
patent: 2008/0014196 (2008-01-01), Yan
patent: 2008/0107648 (2008-05-01), Noguera et al.
patent: 2008/0175847 (2008-07-01), Yan
patent: 2008/0187532 (2008-08-01), Gurney et al.
patent: 0861894 (2006-03-01), None
patent: 0972041 (2006-10-01), None
patent: WO 97/01571 (1997-01-01), None
patent: WO 98/45434 (1998-10-01), None
patent: WO98/45434 (1998-10-01), None
patent: WO98/51799 (1998-11-01), None
patent: WO 00/06726 (2000-02-01), None
patent: WO2008/042236 (2008-04-01), None
Rudikoff et al. Proc Natl Acad Sci USA 1982 vol. 79 p. 1979.
MacCallum et al. J. Mol. Biol. (1996) 262, 732-745.
Pascalis et al. The Journal of Immunology (2002) 169, 3076-3084.
Casset et al. BBRC 2003, 307:198-205.
Vajdos et al. J. Mol. Biol. (2002) 320, 415-428.
Chen et al. J. Mol. Bio. (1999) 293, 865-881.
Wu et al. J. Mol. Biol. (1999) 294, 151-162.
Padlan et al. PNAS 1989, 86:5938-5942.
Lamminmaki et al. JBC 2001, 276:36687-36694.
Shutter et al. (2000) DLL4, A Novel Notch Ligand . . . Genes & Development 14:1313-1318.
Krebs et al. (2004) Haploinsufficient Lethality and Formation . . . Genes & Development 18:2469-2473.
Gale et al. (2004) Haploinsufficiency of Delta-Like 4 Ligand Results . . . PNAS USA 101 (45) :15949-15954.
Duarte et al. (2004) Dosage-Sensitive Requirement for Mouse DLL4 . . . Genes & Development 18:2474-2478.
Lauret, E et al. 2004. Membrane-bound Delta-4 Notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+ CD38low cells while maintaining their LTC-IC potential. Leukemia 18(4):788-797.
Williams, CK et al. 2006. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 107(3):931-939.
Hainaud, Patricia et al. 2006. The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions. Cancer Research 66(17): 8501-8510.
Dando, Jonathan S et al. 2005. Notch/Delta4 interaction in human embryonic liver CD34+ CD38- cells: positive influence on BFU-E production and LTC-IC potential maintenance. Stem Cells 23(4): 550-560.
Sugimoto et al. 2006. Delta-4 Notch ligand promotes erythroid differentiation of human umbilical cord blood CD34+ cells. Experimental Hematology 34(4): 424-432.
Dorsch, Marion et al. 2002. Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. Blood 100(6): 2046-2055.
Liu, Zhao-Jun et al. 2006. Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1. FASEB Journal 20(7): E201-E210.
Noguera-Troise, Irene et al. 2006. Blockade of DLL4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444(7122): 1032-1037.
Martin Joel H.
Noguera-Troise Irene
Papadopoulos Nicholas J.
Smith Eric
Thurston Gavin
Gregg, Esq. Valeta
Natarajan Meera
Regeneron Pharmaceuticals Inc.
Yokoyama, Esq. Izumi
Yu Misook
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