Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-06-05
2007-06-05
Blanchard, David J. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388150, C530S388850, C530S391300, C530S391700, C424S133100, C424S142100, C424S156100, C424S174100, C424S181100, C424S183100, C435S069600, C536S023530
Reexamination Certificate
active
09403107
ABSTRACT:
The present invention provides an anti-human antibody or fragment thereof that is low or not immunogenic in humans. In particular, the antibodies or fragments are directed to human tumor antigens, preferably to the human tumor antigen 17-1A, also known as EpCAM, EGP or GA 733-2. Also provided are pharmaceutical compositions comprising the aforementioned antibodies or fragments thereto.
REFERENCES:
patent: 5565332 (1996-10-01), Hoogenboom et al.
patent: 5885793 (1999-03-01), Griffiths et al.
patent: 6150584 (2000-11-01), Kucherlapati et al.
patent: WO 93/11236 (1993-06-01), None
patent: WO 97/00271 (1997-01-01), None
Rudikoff et al (Proc Natl Acad Sci USA 1982 vol. 79 p. 1979).
Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p. 4.
Dermer (Bio/Technology, 1994, 12:320).
Gura (Science, 1997, 278:1041-1042).
Jain (Sci. Am., 1994, 271:58-65).
William E. Paul. Fundamental Immunology, 3rd edition, pp. 292-295, 1993.
Albert F. LoBuglio et al.,Proc. Natl. Acad. Sci, 86:4220-4224, 1989.
Duenas et al.: In vitro immunization of naïve human B cell yields high affinity immunoglubulin G antibodies as illustrated by phage display. IMMUNOLOGY, vol. 89, No. 1, Sep. 1996, pp. 1-7, XP002093905 Oxford, GB.
A. Krebber et al.: “Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoire employing a reengineered phage display system”, Journal of Immunological Methods, vol. 201, No. 1, Feb. 14, 1997, pp. 35-35, XP002093906 Amsterdam, The Netherlands.
H. Göttlinger et al.: “The epithelial cell surface antigen 17-1A, a target for antibody-medicated tumor therapy: its biochemical nature, tissue distribution and recognition by different monoclonal antibodies” International Journal of Cancer, vol. 38, No. 1, Jul. 15, 1986, pp. 47-53, XP002093908 New York, NY, USA.
A. Hoess et al.: “Generation of human antibodies that selectively recognize diseased cells overexpressing surface bound antigens.” Proceedings of the American Association for Cancer Research vol. 38, Mar. 1997, p. 30 XP002093904 USA, Abstract #198.
Figini et al., “In vitro assembly of repertoires of antibody chains on the surface of phage by renaturation,”J. Mol. Biol.,239:68-78, 1994.
Marks et al., “By-passing immunization human antibodies from V-gene libraries displayed on phage,”J. Mol. Biol.,222:581-597, 1991.
U.S. Appl. No. 10/325,694, filed Dec. 19, 2002, Kufer.
Herlyn et al. “Colorectal carcinoma-specific antigen: Detection by means of monoclonal antibodies,”Proc. Natl. Acad. Sci.,76:1438-1442, 1979.
Herlyn et al., “IgG2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells,”Proc. Natl. Acad. Sci.,79:4761-4765, 1982.
Litvinov et al., “Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule,”Department of Pathology, State University of Leiden, Leiden, The Netherlands,125:437-446, 1994.
Sun et al., “Chimeric antibody with human constant regions and mouse variable regions directed against carcinoma-associated antigen 17-1A,”Proc. Natl. Acad. Sci.,84:214-218, 1987.
Kufer Peter
Raum Tobias
Blanchard David J.
Fulbright & Jaworski
Micromet AG
LandOfFree
Human antibodies that bind human 17-A1/EpCAM tumor antigen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human antibodies that bind human 17-A1/EpCAM tumor antigen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human antibodies that bind human 17-A1/EpCAM tumor antigen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3857765