Multicellular living organisms and unmodified parts thereof and – Method of making a transgenic nonhuman animal – Via microinjection of dna into an embryo – egg cell – or...
Patent
1995-06-07
2000-06-13
Hauda, Karen M.
Multicellular living organisms and unmodified parts thereof and
Method of making a transgenic nonhuman animal
Via microinjection of dna into an embryo, egg cell, or...
800 21, 800 18, 800 4, 800 6, A61K 4800, C12N 1509, C12N 510
Patent
active
060751819
ABSTRACT:
Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
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Brenner Daniel G.
Capon Daniel J.
Jakobovits Aya
Klapholz Sue
Kucherlapati Raju
Abgenix, Inc.
Gunnison Jane T.
Haley, Jr. James F.
Hauda Karen M.
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