Human antibodies as detection reagents

Details Human antibodies as detection reagents Human antibodies as detection reagents

2007-03-13

2007-03-13

Saunders, David (Department: 1644)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007940, C435S962000, C435S973000, C436S518000, C436S809000, C530S388150, C530S391100

Reexamination Certificate

active

10149737

ABSTRACT:
The invention provides in vitro methods of detection using human antibodies. The methods are particularly useful for analyzing human samples containing HAMA or heterophilic antibodies. A human antibody can bind to an analyte in such samples without binding to HAMA or heterophilic antibodies present in the samples. The methods can be effected using a sandwich format among others.

REFERENCES:
patent: 3654090 (1972-04-01), Schuurs et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4486530 (1984-12-01), David et al.
patent: 4514505 (1985-04-01), Canfield et al.
patent: 5173418 (1992-12-01), Molin et al.
patent: 5427908 (1995-06-01), Dower
patent: 5486452 (1996-01-01), Gordon et al.
patent: 5545807 (1996-08-01), Surani et al.
patent: 5565332 (1996-10-01), Hoogenboom et al.
patent: 5571698 (1996-11-01), Ladner et al.
patent: 5595898 (1997-01-01), Robinson et al.
patent: 5625126 (1997-04-01), Lonberg et al.
patent: 5658727 (1997-08-01), Barbas et al.
patent: 5667988 (1997-09-01), Barbas et al.
patent: 5766905 (1998-06-01), Studier et al.
patent: 5770429 (1998-06-01), Lonberg et al.
patent: 5789208 (1998-08-01), Sharon
patent: 5811524 (1998-09-01), Brams et al.
patent: 5874312 (1999-02-01), Sredni et al.
patent: 5914241 (1999-06-01), Valkirs
patent: 5939807 (1999-08-01), Patyk et al.
patent: 6057098 (2000-05-01), Buechler et al.
patent: 6090382 (2000-07-01), Salfeld et al.
patent: 6261558 (2001-07-01), Barbas et al.
patent: 6335163 (2002-01-01), Sharon
patent: 6420113 (2002-07-01), Buechler et al.
patent: 251 612 (1988-01-01), None
patent: 934 953 (1999-08-01), None
patent: WO 91/19818 (1991-02-01), None
patent: WO 92/06204 (1992-04-01), None
patent: WO 94/26787 (1994-11-01), None
patent: 9511317 (1995-04-01), None
patent: WO 96/33735 (1996-10-01), None
patent: WO 98/06704 (1998-02-01), None
patent: WO 98/47343 (1998-10-01), None
patent: WO 99/45962 (1999-09-01), None
patent: WO 99/53049 (1999-10-01), None
patent: WO 01/25492 (2001-12-01), None
Cwirla et al., “Peptides on Phage: A Vast Library of Peptides for Identifying Ligands,”PNAS, 87:6378-82 (1990).
Devlin et al., “Random Peptide Libraries: A Source of Specific Protein Binding Molecules,”Science, 249:404-406 (1990).
Georgiou et al., “Display of Heterologous Proteins on the Surface of Microorganisms: From the Screening of Combinatorial Libraries to Live Recombinant Vaccines,”Nature Biotech., 15:29-34 (1997).
Kricka, L.J., “Human Anti-Animal Antibody Interferences in Immunological Assays,”Clinical Chemistry, 45(7):942-956 (1999).
Kuijper et al., “Functional cloning vectors for use in directional cDNA cloning using cohesive ends produced with T4 DNA polymerase,”Gene, 112(2):147-155 (1992).
McCafferty et al., “Selection and Rapid Purification of Murine Antibody Fragments That Bind a Transition-State Analog by Phage Display,”Applied Biochem. &Biotech., 47:157-173 (1994).
Scott et al., “Searching for Peptide Ligands With An Epitope Library,”Science, 249:386-388 (1990).
Winter et al., “Making Antibodies by Phage Display Technology,”Annu. Rev. Immunol., 12:433-455 (1994).
Rader et al., “Phage display of combinatorial antibody libraries,”Current Opinion in Biotech. 8:503-508 (1997).
Claeys et al., “HIV1-Virus is not Inactivated by Buthylated Hydroxytoluene (BHT) In Vitro,”Medical Hypotheses, 27:145-146 (1988).
Konig et al., “Use of an albumin-binding domain for the selective immobilization of recombinant capture antibody fragments on ELISA plates,”J. Immunological Methods, 218:73-83 (1998).
Mendez et al., “Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice,”Nature Genetics, 15(2):146-156 (1997).
Vaughan et al., “Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library,”Nature Biotechnology, 14:309-314 (1996).

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