Human antibodies against varicella-zoster virus

Details Human antibodies against varicella-zoster virus Human antibodies against varicella-zoster virus

1994-03-24

1996-04-09

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

43524027, 4353201, 5303873, 53038815, 5303883, 536 2353, C12N 510, C07K 1608, C07H 1512

Patent

active

055061320

ABSTRACT:
The invention provides human monoclonal antibodies specific for the glycoprotein II subunit of Varicella-zoster virus. Preferred antibodies exhibit strong complement-independent neutralizing activity, antibody dependent cellular cytotoxicity, and cross-reactivity with multiple strains of Varicella-zoster virus.

REFERENCES:
Sugano et al., Eur. J. Immunol., 17:359-64, 1987.
Ostberg et al., Hybridoma 2:361-367, 1983.
Morrison, Science 229:1202-1207, 1985.
Waldmann, Science 252:1657-1662, 1991.
Casale et al. Science 234:476-79, 1986.

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