Human antibodies against Pseudomonas aeruginosa LPS...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...

Reexamination Certificate

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C424S170100, C530S388400

Reexamination Certificate

active

07972845

ABSTRACT:
The invention described herein provides for human antibodies produced in non-human animals that specifically bind toPseudomonas aeruginosaLipopolysaccharide (LPS). The invention further provides methods for making the antibodies in a non-human animal, expression of the antibodies in cell lines including hybridomas and recombinant host cell systems. Also provided are kits and pharmaceutical compositions comprising the antibodies and methods of treating or preventing pseudomonas infection by administering to a patient the pharmaceutical compositions described herein.

REFERENCES:
patent: 0 441 395 (1991-08-01), None
patent: WO 96/33735 (1996-10-01), None
Greenspan et al. (Nature Biotechnology 17: 936-937, 1999).
Bowie et al (Science, 1990, 247:1306-1310).
Hemachandra et al., “Human Monoclonal Antibody (Mab) againstPseudomonas AeruginosaLPS Derived from Transgenic XenoMouse™ Mice Is Opsonic and Highly Protective in the Neutropenic Mouse Model of Sepsis,”Clin. Infect. Dis.31:213 2000.
Hemachandra et al., “Human Monoclonal Antibodies againstPseudomonas aeruginosaLipopolysaccharide Derived from Transgenic Mice Containing Megabase Human Immunoglobulin Loci Are Opsonic and Protective against Fatal Pseudomonas Sepsis,”Infect. Immun.69:2223-29 2001.
Lang et al., “Isolation and Characterization of a Human Monoclonal Antibody that Recognizes Epitopes Shared byPseudomonas aeruginosaImmunotype 1, 3, 4, and 6 Lipopolysaccharides,”Infect. Immun.57:3851-55 (1989).
Mendez et al., “Functional Transplant of Megabase Human Immunoglobulin Loci Recapitulates Human Antibody Response in Mice,”Nature Genet.15:146-56 (1997).
Preston et al., “Production and Characterization of a Set of Mouse-Human Chimeric Immunoglobulin G (IgG) Subclass and IgA Monoclonal Antibodies with Identical Variable Regions Specific forPseudomonas aeruginosaSerogroup O6 Lipopolysaccaride,”Infect. Immun.66:4137-42 (1998).
Sawada et al., “Immunoprotective Human Monoclonal Antibodies Against Five Major Serotypes ofPseudomonas aeruginosa,” J. Gen. Microbiol.133:3581-90 (1987).
Hatano et al , “Immunogenic and Antigenic Properties of a Heptavalent High-Molecular-Weight O-Polysaccharide Vaccine Derived fromPseudomonas aeruginosa,” Infection and Immunity, 62(9):3608-3616 (1994).
Rudikoff et al., “Single amino acid substitution altering antigen-binding specificity,”Proc. Natl. Acad. Sci. USA, 79:1979-1983 (1982).
Zweerink et al., “Human monoclonal antibodies that protect mice against challenge withPseudomonas aeruginosa,” Infection and Immunity, 56(8):1873-1879 (1988).

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