Human antibodies against eotaxin

Details Human antibodies against eotaxin Human antibodies against eotaxin

2005-09-20

2005-09-20

Gambel, Phillip (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S387100, C530S388100, C530S388200, C530S388230, C530S351000

Reexamination Certificate

active

06946546

ABSTRACT:
Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralize eotaxin-1 activity. The antibody VH and/or VL domain of the scFv fragment herein termed CAT-212 and of the IgG4 antibody herein termed CAT-213. One or more complementarity determining regions (CDRs) of the CAT-212/-213 VH and/or VL domains, especially VH CDR3 in other antibody framework regions. Compositions containing specific binding members, and their use in methods of inhibiting or neutralizing eotaxin, including methods of treatment of the human or animal body by therapy.

REFERENCES:
patent: 5993814 (1999-11-01), Williams et al.
patent: 6031080 (2000-02-01), Williams et al.
patent: 6403782 (2002-06-01), Luster et al.
patent: 0 546 634 (1993-06-01), None
patent: 2 350 612 (2000-06-01), None
patent: WO 91/07492 (1991-05-01), None
patent: WO 93/02190 (1993-02-01), None
patent: WO 97/00960 (1997-01-01), None
patent: 97/12914 (1997-04-01), None
patent: 99/10534 (1999-03-01), None
patent: WO 01/14424 (2001-03-01), None
patent: 02/02640 (2002-01-01), None
Ward et al. Nature 341: 544-546 (1989).
Reiter et al. J. Mol Biol. 290: 685-698 (1999).
Marks et al. Bio/Technology 10: 779-783 (1992).
Xu and Davis Immunity 13: 37-45 (2000).
Bendig Methods: A Companion to Methods in Enzymology 1995;8:83-93.
D. Griffiths-Johnson et al., “The Chemokine, Eotaxin, Activates Guinea-Pig Eosinophils In Vitro and Causes Their Accumulation into the Lung In Vivo ”Biochem.&BioPhys. Res. Comm.197:1167-1172 (Dec. 30, 1993).
Jose et al., “Eotaxin: A Potent Eosinophil Chemoattractant Cytokine Detected in a Guinea Pig Model of Allergic Airways Inflammation, ”J. Exp. Med.179:881-887 (Mar. 1, 1994).
Jose et al., “Eotaxin: Cloning of an Eosinophil Chemoattractant Cytokine and Increased mRNA Expression in Allergen-Challenged Guinea-Pig Lungs,”Biochem&BioPhys. Res. Comm.205(1):788-794 (Nov. 30, 1994).
Genbank Acc. No. BAA08370 Eotaxin (Internet website //www.ncbi.nlm.nih.gov).
Ponath et al., “Cloning of the Human Eosinophil Chemoattractant , Eotaxin Expression, Receptor Binding and Functional Properties Suggest a Mechanism for the Selective Recruitment of Eosinophils,”J. Clin. Invest. 97:604-612 (1996).
Kitaura et al., “Molecular Cloning of Human Eotaxin, an Eosinophil-selective CC Chemokine and Identificiation of a Specific Eosinophil Eotaxin Receptor, CC Cehmokine Receptor 3,”J. Biol. Chem.271:7725 (1996).
Nakajima et al., “Intracellular Localization and Release of Eotaxin from Normal Eosinophils,”FEBS Letters, 20625:226-230 (1998).
Pech et al., “Organization and Evolution of a Gene Cluster for Human Immunoglobulin Variable Regions of the Kappa Type,”J. Mol. Biol., 176(2):189-204 (1984).
Bensimon et al., “Human Lupus Anti-DNA Autoantibodies Undergo Essentially Primary V X Gene Rearrangements,”The EMBRO Journal; 13(13):2951-2962 (1994).
Garcia-Zepeda et al., “Human Eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia,” Nat. Med. 4:449-456 (Apr., 1996).

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