Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-05-05
1997-08-05
Budens, Robert D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
4241421, 4241451, 4241581, 435335, 53038823, 53038824, C07K 1624
Patent
active
056544073
ABSTRACT:
Human monoclonal antibodies (mAbs) which bind to human TNF.alpha. are disclosed. Autoantibodies of both the IgM and IgG isotypes are disclosed. A preferred human monoclonal antibody is known as B5 (F78-1A10-B5 mAb) and it binds to recombinant human TNF.alpha. (rhTNF.alpha.) in ELISA format with a titer comparable to three high affinity neutralizing mouse mAbs. It also binds to cell surface TNF.alpha. and prevents TNF.alpha. secretion by human monocyte cell lines.
REFERENCES:
Rhein, R., "Another Sepsis Drug Down--Immunex' TNF Receptor,"Biotechnology Newswatch Oct. 4, 1993, McGraw Hill, Publishers., pp. 2-3.
Boyle et al., "A Novel Monoclonal Human IgM Autoantibody Which Binds Recombinant Human and Mouse Tumor Necrosis Factor-.alpha.," Cell. Immunol. 152:556-568, 1993.
Boyle et al., "The B5 Monoclonal Human Autoantibody Binds to Cell Surface TNF.alpha. on Human Lymphoid Cells and Cell Lines and Appears to Recognize a Novel Epitope," Cell. Immunol. 152:569-581, 1993.
Boyle Petra
Lembach Kenneth J.
Wetzel Gayle D.
Bayer Corporation
Budens Robert D.
Giblin James A.
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