Human anti-RH(D) monoclonal antibodies reagents and hybridomas a

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

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4241531, 53038815, 5303887, 435 725, 43524027, 4351722, 435 7021, A61K 39395, C07K 1634, C12N 522, G01N 3353

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active

054878918

ABSTRACT:
The present invention provides human monoclonal antibodies having the following essential characteristics: (a) binding to Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system; (b) being IgGl proteins; (c) having kappa light chains; (d) being Glm(3) or Glm(1,17) allotype; (e) binding to D.sup.u cells by an indirect antiglobulin test; (f) binding to D.sup.IV, D.sup.V and D.sup.VII variant antigens; and (g) not binding to D.sup.VI or D.sup.B variant antigens, which may be employed for Rh-typing of red blood cells and passive immunization to prevent hemolytic disease of the newborn. Such a monoclonal antibody is exemplified by the monoclonal antibodies of cell lines ECACC 87091605 and 87091604 deposited at the European Collection of Animal Cell Cultures, Public Health Laboratory Service Center for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4, OJG, England on 16th September 1987.

REFERENCES:
Bron et al., PNAS 81:3214-3217, 1984.
McConn et al., J. Immunol. Mtds 115:3-15, 1988.
Thomson et al., The Lancet 336:1147-1150, 1990.
Doyle et al., Human Immunology 13:199-209, 1985.
Thompson et al., Immunology 58:157-160, 1986.
Paire et al., Immunology Letters 13:137-41, 1986.
Kumpel et al., British J. Hematology 71:125-129, 1989.
Mollison, P. L. in "Hemolytic Disease of the Newborn", Garrity, G. Ed., American Assoc. Blood Banks, 1984, pp. 1-32.
Lomas et al., Transfusion 26:560, 1986.
Tippett, Med. Lab. Sci., 45:88-93, 1988.

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