Human anti-Fas IgG1 monoclonal antibodies

Details Human anti-Fas IgG1 monoclonal antibodies Human anti-Fas IgG1 monoclonal antibodies

1994-10-13

1997-04-15

Loring, Susan A.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

5303882, 53038824, 53038823, 5303871, 53038875, 435334, 4353432, 4241441, C12N 512, C07K 1618, C07K 1622, C07K 1628

Patent

active

056208898

ABSTRACT:
The present invention provides a panel of monoclonal antibodies and binding proteins which specifically bind to human Fas antigen. Some of the antibodies and binding proteins are capable of stimulating T cell proliferation, inhibiting binding of anti-Fas CH-11 monoclonal antibody to cells expressing Fas antigen, blocking anti-Fas CH-11 monoclonal antibody-mediated lysis of cells, and blocking Fas ligand-mediated lysis of cells. The invention also provides for therapeutic compositions comprising the monoclonal antibodies.

REFERENCES:
Dhein et al., J. Immunology, 149(10):3166-3174 (1992).
Itoh et al., Cell, 66:233-243 (1991).
Klas et al., International Immunology, 5:625-630 (1993).
Kobayashi et al., Proc. Natl. Acad. Sci., USA, 87:9620-9624 (1990).
Miyawaki et al., J. Immunology, 149(11):3753-3758 (1992).
Ogasawara et al., Nature, 364:806-809 (1993).
Trauth et al., Science, 245:301-305 (1989).
Yonehara et al., J. Exp. Med., 169:1747-1756 (1989).
Owen-Schaub et al., Cellular Immunology, 140:197-205 (1992).
Jian et al., Arthritis and Rheumatism, 36(Suppl 9):s52, Abstract No. 80 (1993).
Zhou et al., Arthritis and Rheumatism, 36(Suppl 9):s52, Abstract No. 81 (1993).
Sevier et al., Clin. Chem., 27(11):1797-1806 (1981).
Allen et al., J. Exp. Med., 172:1367-1375 (1990).
Winter et al., TIPS, 14:139-143 (1993).
Alderson et al., J. Exp. Med., 178:2231-2235 (1993).
Rhein, Biotechnology Newswatch, pp. 1 and 3 (1993).
Itoh et al., J. Immunol., 151:621-627 (1993).

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