Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2006-05-16
2006-05-16
Mertz, Prema (Department: 1646)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C424S001110, C424S001490, C530S387100, C530S387300
Reexamination Certificate
active
07045127
ABSTRACT:
Human anti-epidermal growth factor receptor (EGFR) single-chain antibodies (scFvs) were isolated from a human IgM phage display library using purified epidermal growth factor receptor as antigen. Two isolates with different amino acid sequences were identified by ELISA as epidermal growth factor receptor-specific. The scFvs bind to the full length epidermal growth factor receptor and the truncated and/or mutated epidermal growth factor receptor on human cells. These anti-EGFR-scFvs are useful as therapeutic and/or diagnostic agents.
REFERENCES:
Beerli et al. Breast Cancer Research and Treatment, vol. 38, 1996, pp. 11-17.
Bonner James Alan
Curiel David T.
Raisch Kevin Paul
Adler Benjamin Aaron
Mertz Prema
The UAB Research Foundation
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