Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-03-21
2009-10-06
Spector, Lorraine (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
Reexamination Certificate
active
07598350
ABSTRACT:
The present invention provides a fully human antibody that binds human EGFR with affinity comparable to or higher than IMC-C225, and that neutralizes activation of EGFR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chains antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells and animals that encode and express these antibodies. The invention further provides a method for neutralizing activation of EGFR, treating in a mammal with neoplastic growth and non-cancerous hyperproliferative diseases using the antibodies alone or in combination with other agents.
REFERENCES:
patent: 4186567 (1980-02-01), Monden et al.
patent: 4510924 (1985-04-01), Gray
patent: 4763642 (1988-08-01), Horowitz
patent: 4816397 (1989-03-01), Boss et al.
patent: 4816401 (1989-03-01), Taupier et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4846782 (1989-07-01), Bonnem
patent: 4863902 (1989-09-01), Amagase et al.
patent: 4943533 (1990-07-01), Mendelsohn et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5196446 (1993-03-01), Levitzki et al.
patent: 5225539 (1993-07-01), Winter et al.
patent: 5260203 (1993-11-01), Ladner et al.
patent: 5455030 (1995-10-01), Ladner et al.
patent: 5468754 (1995-11-01), Hausheer et al.
patent: 5470571 (1995-11-01), Herlyn et al.
patent: 5518889 (1996-05-01), Ladner et al.
patent: 5545807 (1996-08-01), Surani et al.
patent: 5550114 (1996-08-01), Strayer
patent: 5558864 (1996-09-01), Bendig et al.
patent: 5559235 (1996-09-01), Luzzio et al.
patent: 5565332 (1996-10-01), Hoogenboom et al.
patent: 5604233 (1997-02-01), Hausheer et al.
patent: 5616582 (1997-04-01), Barker et al.
patent: 5646153 (1997-07-01), Spada et al.
patent: 5656655 (1997-08-01), Spada et al.
patent: 5658570 (1997-08-01), Newman et al.
patent: 5663144 (1997-09-01), Greene et al.
patent: 5677171 (1997-10-01), Hudziak et al.
patent: 5679683 (1997-10-01), Bridges et al.
patent: 5693780 (1997-12-01), Newman et al.
patent: 5705157 (1998-01-01), Greene
patent: 5707632 (1998-01-01), Williams et al.
patent: 5736534 (1998-04-01), Arnold
patent: 5770195 (1998-06-01), Hudziak et al.
patent: 5770599 (1998-06-01), Gibson et al.
patent: 5789427 (1998-08-01), Chen et al.
patent: 5837242 (1998-11-01), Holliger et al.
patent: 5840301 (1998-11-01), Rockwell et al.
patent: 5844093 (1998-12-01), Kettleborough et al.
patent: 5846565 (1998-12-01), Brem et al.
patent: 5851999 (1998-12-01), Ullrich et al.
patent: 5855885 (1999-01-01), Smith et al.
patent: 5859205 (1999-01-01), Adair et al.
patent: 5861499 (1999-01-01), Rockwell et al.
patent: 5866363 (1999-02-01), Pieczenik
patent: 5866572 (1999-02-01), Barker et al.
patent: 5869465 (1999-02-01), Morgan, Jr. et al.
patent: 5880133 (1999-03-01), Hausheer et al.
patent: 5885793 (1999-03-01), Griffiths et al.
patent: 5886363 (1999-03-01), Hamada et al.
patent: 5891996 (1999-04-01), Mateo de Acosta del Rio et al.
patent: 5914269 (1999-06-01), Bennett et al.
patent: 5925566 (1999-07-01), Davis et al.
patent: 5942602 (1999-08-01), Wels et al.
patent: 5955311 (1999-09-01), Rockwell et al.
patent: 5969108 (1999-10-01), McCafferty et al.
patent: 6004967 (1999-12-01), McMahon et al.
patent: 6129915 (2000-10-01), Wels et al.
patent: 6140317 (2000-10-01), Traxler et al.
patent: 6217866 (2001-04-01), Schlessinger et al.
patent: 6235883 (2001-05-01), Jakobovits et al.
patent: 6265411 (2001-07-01), Thomas et al.
patent: 6417168 (2002-07-01), Greene et al.
patent: 6506883 (2003-01-01), Meteo de Acosta del Rio et al.
patent: 6605448 (2003-08-01), Pieczenik
patent: 6632927 (2003-10-01), Adair et al.
patent: 6639055 (2003-10-01), Carter et al.
patent: 6685940 (2004-02-01), Andya et al.
patent: 6699473 (2004-03-01), Raisch et al.
patent: 2003/0105057 (2003-06-01), Fu et al.
patent: 2003/0157104 (2003-08-01), Waksal
patent: 2003/0194403 (2003-10-01), van de Winkel et al.
patent: 2004/0022785 (2004-02-01), Clinton et al.
patent: 2004/0057950 (2004-03-01), Waksal et al.
patent: 2004/0116330 (2004-06-01), Naito et al.
patent: 2005/0112120 (2005-05-01), Waksal
patent: 2005/0148607 (2005-07-01), Suzuki et al.
patent: 2005/0176633 (2005-08-01), Ullrich et al.
patent: 2005/0220786 (2005-10-01), Mahler et al.
patent: 2005/0281814 (2005-12-01), Buchsbaum
patent: WO/98/50433 (1998-05-01), None
patent: WO/03/064606 (2003-08-01), None
patent: WO/2004/005890 (2004-01-01), None
Janeway et al. eds., chapter 3, Immunobiology, chapter 3, Garland publishing, New York, 2001, ISBN 081533642 X.
Rudikoff et al., Single amino acid substitution altering antigen-binding specificit. Proc. Natl. Acad. Sci. USA, 79, 1979-1983, 1982.
Kobrin et al., A V Region Mutation in a Phosphocholine-Binding Monoclonal Antibody Results in Loss of Antigen Binding, J. Immunol., 146, 2017-2020, 1991.
Barrios et al., Length of the antibody heavy chain complementarity determining region 3 as aspecificity-determining factor. J. Mol. Recog., 17, 332-338, 2004.
Sliwkowski et al., Journal of Biological Chemistry 269:14661-5 (1994).
Snider et al., Ann Thorac Surg 62:1454 (1996).
Stanton et al., Br. J. Cancer 70(3):427-33 Abstract Only (1994).
Tzahar et al., The EMBO Journal 16:4938-50 (1997).
Van Gog et al., Int. J. Cancer 77:13 (1998).
Visakorpi et al., Mod. Pathol. 5(6):643-8 (1992).
Walter et al., PNAS 77:5197-5200 (1980).
Wazer et al., Br. J. Radiology 62:1079-83 (1989).
Witters et al., Breast Cancer Research Treatment 42:1 (1997).
Wollman et al., Int. J. Radiat. Oncol. Biol. Phys. 30(1):91-98 (1994).
Yang et al., PNAS 85:1189-93 (1988).
Zaks, et al., Cancer Research 58:4902-8 (1998).
Zhang & Hung, Oncogene 12:571-75 (1996).
Liu Meilin
Zhu Zhenping
Cox Gregory A.
ImClone LLC
Spector Lorraine
Stoica Elly-Gerald
LandOfFree
Human anti-epidermal growth factor receptor antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human anti-epidermal growth factor receptor antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human anti-epidermal growth factor receptor antibody will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4089387