Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2005-02-08
2005-02-08
Leffers, Gerry (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C435S235100, C435S006120, C435S069100, C435S069700, C435S455000, C514S04400A, C536S023100, C536S023400, C536S024100
Reexamination Certificate
active
06852528
ABSTRACT:
The invention provides new urothelial cell specific transcriptional regulatory sequences derived from human uroplakin II (hUPII), as well as polynucleotide constructs such as adenoviral vectors and methods of using hUPII-derived TREs. Additionally, the invention provides adenoviral vectors comprising a gene, preferably an adenovirus gene, under transcriptional control of a urothelial cell-specific transcriptional regulatory element (TRE). These vectors display urothelial cell-specific cytotoxicity, which is especially useful in the context of bladder cancer, in which destruction of these cells is desirable. The invention further provides compositions and host cells comprising the vectors, as well as method of using the adenoviral vectors.
REFERENCES:
patent: 5670367 (1997-09-01), Dorner et al.
patent: 5698443 (1997-12-01), Henderson et al.
patent: 5824543 (1998-10-01), Sun
patent: 5994128 (1999-11-01), Fallaux et al.
patent: 5998205 (1999-12-01), Hallenbeck et al.
patent: 6001646 (1999-12-01), Sun
patent: 6692736 (2004-02-01), Yu et al.
patent: WO 9519434 (1995-07-01), None
patent: WO 9639494 (1996-12-01), None
patent: WO 9701358 (1997-01-01), None
patent: WO 9839465 (1998-09-01), None
patent: WO 9839466 (1998-09-01), None
patent: WO 9839467 (1998-09-01), None
patent: WO 9906576 (1999-02-01), None
patent: WO 9925810 (1999-05-01), None
patent: WO 9925860 (1999-05-01), None
Lin, Jun-Hsiang et al., “A tissue-specific promoter that can drive a foreign gene to express in the suprabasal urothelial cells of transgenic mice,”Proc. Natnl. Acad. Sci. USA, vol. 92, pp. 679-683, Jan. 1995.
Henderson Daniel R.
Yu De-Chao
Zhang Hong
Bozicevic Field & Francis LLP
Cell Genesys Inc.
Judge Linda R.
Leffers Gerry
Sherwood Pamela J.
LandOfFree
Human and mouse uroplakin II gene transcriptional regulatory... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human and mouse uroplakin II gene transcriptional regulatory..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human and mouse uroplakin II gene transcriptional regulatory... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3502627