Human and mammalian stem cell-derived neuron survival factors

Details Human and mammalian stem cell-derived neuron survival factors Human and mammalian stem cell-derived neuron survival factors

2004-04-28

2010-02-16

Stucker, Jeffrey (Department: 1649)

Chemistry: molecular biology and microbiology

Vector, per se

C435S325000, C536S023100, C536S023500, C536S024300

Reexamination Certificate

active

07662620

ABSTRACT:
The present invention relates to human, rat and mouse stem cell-derived neuron survival factor polypeptides (SDNSF), a process for producing them, cDNA encoding SDNSF, a vector comprising the cDNA, host cells transformed by the vector, an antibody against SDNSF, pharmaceutical compositions containing SDNSF or the antibody, a method of assaying SDNSF, a reagent for assaying SDNSF, and a screening method using SDNSF. The polypeptides are effective in the survival of nerve cells and neuronal stem cells, therefore, efficacious in treating injury to the central nerve system and cancer.

REFERENCES:
patent: WO 99/18204 (1999-04-01), None
patent: WO 01/21658 (2001-03-01), None
Hsich et al., Human Gene Therapy, vol. 13, 2002, pp. 579-604.
Piao et al., Genome Research, vol. 11, 2001, pp. 1553-1558.
GenBank accession No. BF021643, Dec. 29, 2000.
Philippe Taupin et al., “FGF-2-Responsive Neural Stem Cell Proliferation Requires CCg, A Novel Autocrine/Paracrine Cofactor”, Neuron (2000) vol. 28, pp. 385-397.
D. D. Sabatini et al., “The Signal Sequence Trap Method”, Methods in Enzymology (1999) vol. 303, pp. 479-495.
Hiroki Toda et al., “Stem Cell-derived Neural Stem/Progenitor Cell Supporting Factor Is an Autocrine/Paracrine Survival Factor for Adult Neural Stem/Progenitor Cells”, The Journal of Biological Chemistry (2003), vol. 278, No. 37, pp. 35491-35499.
Supplementary European Search Report dated Dec. 9, 2004.

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