Human analogs of murine deubiquitinating proteases

Details Human analogs of murine deubiquitinating proteases Human analogs of murine deubiquitinating proteases

2007-04-10

2007-04-10

Swope, Sheridan (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

Reexamination Certificate

active

10371905

ABSTRACT:
The present invention is directed to human analogs of murine hematopoetic-specific, cytokine-inducible deubiquinating proteases (“DUBs”) clustered on chromosomes 4 and 8 and their respective regulatory regions. The nucleotides or proteins encoded thereby my be used in assays to identify inhibitors of human DUBs.

REFERENCES:
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UniProt—03 database Accession No. Q6R6M4 Jul. 5, 2004 Burrows et al. Alignment with Seq ID No. 2.
Baek Kwang-Hyun et al.,DUB-2A, a New Member of theDUBSubfamily of Hematopoietic Deubiquitinating Enzymes, Blood, Aug. 1, 2001, vol. 98, No. 3, pp. 636-642.
Jaster Robert et al.,JAK2Is Required for Induction of the MurineDUB-1Gene, Molecular and Cellular Biology, Jun. 1997, pp. 3364-3372.
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Jaster Robert et al., Analysis ofcis-acting sequences andtrans-acting factors regulating the interleukin-3 response element of theDUB-1gene, Biochimica et Biophysica Acta vol. 1446, 1999, pp. 308-316.
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Zhu Yuan et al.,DUB-2is a Member of a Novel Family of Cytokine-inducible Deubiquitinating Enzymes, The Journal of Biological Chemistry, Journal of Biological Chemistry, vol. 272, No. 1, Jan. 3, 1997, pp. 51-57.
Zhu Yuan et al., The MurineDUB-1Gene is Specifically Induced by the Bc Subunit ot he Interleukin-3 Receptor, Molecular and Cellular Biology, Sep. 1996, pp. 4808-4817.
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