Human amyloid protein precursor homolog and kunitz-type inhibito

Details Human amyloid protein precursor homolog and kunitz-type inhibito Human amyloid protein precursor homolog and kunitz-type inhibito

1995-04-18

1997-10-14

Furman, Keith C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 692, 43525233, 4352542, 43525421, 435325, C12N 1509, C12N 1515, C12N 1570, C12N 1579

Patent

active

056771460

ABSTRACT:
The present invention provides isolated DNA molecules comprising a DNA segment encoding a novel human amyloid protein precursor homologue and novel Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human amyloid protein precursor homologue or a novel Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.

REFERENCES:
Yan et al., Proc. Natl. Acad. Sci. USA 87:2405-2408, 1990.
Bram et al., Mol. Cell. Biol. 7(1): 403-409, 1987.
Sprecher et al., Biochem. 32: 4481-4486, 1993.
Kido et al., Biochemical and Biophysical Research Communications 167(2): 716-721, 1990.
Holtzman et al., TIBS 16: 140-144, 1991.
Wasco et al., Nature Genetics 5: 95-99, 1993.
Kitaguchi et al., "Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity," Nature 331:530-532 Feb. 11, 1988.

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