Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-02-23
2010-02-16
Falk, Anne-Marie (Department: 1632)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S005000
Reexamination Certificate
active
07662628
ABSTRACT:
The present invention relates to human Akt3 proteins and polypeptides. The invention also relates to isolated nucleic acids encoding human Akt3, to vectors containing them and to their therapeutic uses, in particular for gene therapy. Expression of Akt3 inhibits cell death associated with hypoxia, apoptosis or necrosis.
REFERENCES:
patent: 5958773 (1999-09-01), Monia et al.
patent: 5985635 (1999-11-01), Bandman et al.
patent: 6043090 (2000-03-01), Monia et al.
patent: 6054285 (2000-04-01), Hemmings et al.
patent: 7368420 (2008-05-01), Walsh
patent: 8109197 (1994-04-01), None
patent: WO 97/18303 (1997-05-01), None
patent: WO 00/37613 (2000-06-01), None
patent: WO 00/56866 (2000-09-01), None
patent: WO 00/58473 (2000-10-01), None
patent: WO 00/77190 (2000-12-01), None
Yia-Herttuala et al, (The Lancet, 355: 213-22, 2000.
Hajjar et al, (Circ Res, 86: 616-621, 2000.
O'Neil et al, (The Journal of Clinical Investigation, 115(8): 2059-2064, 2005.
Manning et al, (Cell, 129: 1261-1274, 2007.
Mullonkal et al, (Journal of Investigative Surgery, 20(3): 195-203, 2007.
Ecke et al , Goodman & Gilman's The Pharmacological basis of Therapeutics, McGraw-Hill, New York, NY. pp. 77-101.
Franke et al, Oncogene, 22: 8983-8998, 2003.
Matsui et al (Journal of Molecular and Cellular Cardiology, 38: 63-71, 2005.
Ichijo et al, (Science, 275: 990-94, 1997.
Brodbeck et al (JBC, 274(14): 9133-9136, 1999.
Okubo et al, (JBC, 273(40): 25961-25966, 1998.
Downward et al, (Current Opinion in Cell Biology, 10: 262-267, 1998.
Andrea Kauffmann-Zeh et al., Suppression of c-Myc-induced Apoptosis by Ras Signalling Through PI(3)K and PKB, Nature, vol. 3856, Feb. 6, 1997, pp. 544-548.
Anke Klippel et al., A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through its Pleckstrin Homology Domain, Molecular and Cellular Biology, Jan. 1997, pp. 338-344.
Brian A. Hemmings, Akt Signaling: Linking Membrane Events to Life and Death Decisions, Science, vol. 275, Jan. 31, 1997, pp. 628-630.
Brian A. Hemmings, Ptdlns(3,4,5)P3 Gets Its Message Across, Science, vol. 277, Jul. 25, 1997, p. 534.
Darren A.E. Cross et al., Inhibition of Glycogen Synthase Kinase-3 by Insulin Mediated by Protein Kinase B, Nature, vol. 378, Dec. 1995, pp. 785-789.
Darui R. Alessi et al., Mechanism of Activation of Protein Kinase B by insulin and IGF-1, EMBO Journal, vol. 5, pp. 6541-6551.
David Stokoe et al., Dual Role of Phosphatidylinositol-3,4,5-triphosphate in the Activation of Protein Kinase B, Science, vol. 277, Jul. 25, 1997, pp. 567-570.
George Kulik et al., Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt, Molecular and Cellular Biology, Mar. 1997, pp. 1595-1606.
Henryk Dudek et al., Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt, Science, vol. 275, Jan. 31, 1997, pp. 661-665.
Hidenori Ichijo et al., Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways, Science, vol. 275, Jan. 3, 1997, pp. 90-94.
Hiroaki Konishi et al., Molecular Cloning and Characterization Of A New Member Of The RAC Protein Kinase amily: Association of the Pleckstrin Homology Domain of Three Types of RAC Protein Kinase With Protein Kinase C Subspecies and Betay Subunits of G Proteins, Biochem. & Biophysical Research Comm. vol. 216, No. 2, Nov. 13, 1995, pp. 526-534.
Howard Y. Chang et al., Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx, Science, vol. 281, Sep. 18, 1998, pp. 1860-1862.
Jerry M. Adams et al, The Bcl-2 Protein Family: Arbiters of Cell Survival, Science, vol. 281, Aug. 28, 1998, pp. 1322-1326.
Poustka et al., Database EMBL Nucleotide and Protein Sequences, Sep. 15, 1999, Abstract XP002153016.
Len Stephens et al., Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B, Science, vol. 279, Jan. 30, 1998, pp. 710-714.
M. Barinaga, Is Apoptosis Key in Alzheimer's Disease?, Science, vol. 281, Aug. 28, 1998, pp. 1303-1304.
M. Barinaga, Stroke-Damaged Neurons May Commit Cellular Suicide, Science, vol. 281, Aug. 28, 1998, pp. 1302-1303.
Nancy A. Thornberry et al., Caspases: Enemies Within, Science, vol. 281, Aug. 28, 1998, pp. 1312-1316.
Nicholas Pullen at al., Phosphorylation and Activation of p70s6k by PDK1, Science, vol. 279, Jan. 30, 1998.
Thomas F. Franke et al., Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositoi-3,4-bisphosphate, Science, vol. 275, Jan. 31, 1997, pp. 665-668.
Thomas F. Franke et al., The Protein Kinase Encoded by the Akt Proto-Oncogene Is a Target of the PDFG-Activated Phosphatidylinositol 3-Kinase, Cell, vol. 81. Issue 5, Jun. 2, 1995, pp. 727-736.
W. Robb MacLellan et al., Death by Design, Programme Cell Death in Cardiovascular Biology and Disease, Circulation Research, vol. 81, 1997, pp. 137-144.
Yumiko Okubo et al., insulin-like Growth Factor-I Inhibits the Stress-activated Protein Kinase/c-Jun N-terminal Kinase, Journ. of Biological Chem., vol. 273, No. 40, Oct. 2, 1998, pp. 25951-25966.
Brodbeck et al., A Human Protein Kinase By with Regulatory Phosphorylation Sites in Activation Loop and in the C-terminal Hydrophobic Domain, Journ. of Biological Chem., vol. 274, No. 14, Apr. 2, 1999, pp. 9133-9136.
Walker et al., Activation of Protein Kinase B Beta and y isoforms by Insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vito: Comparison With Protein Kinase B alpha, Biochem, Journal, vol. 331, 1998, pp. 299-308.
Nakatani et al., Identification of a Human Akt3 (Protein Kinase B y) Which Contains the Regulatory Serine Phosphorylation Site, Biochem. and Biophys. Res. Comm. vol. 257, 1999, pp. 906-910.
Matsui et al. Adenoviral Gene Transfer of Activated Phosphatidylinositol 3′-Kinase and Akt Inhibits Apoptosis of Hypoxic Cardiomyocytes In Vitro, U.S. American Heart Association, vol. 100, No. 23, Dec. 7,1999, pp. 2373-2379.
J. Downward, Mechanisms and Consequences Of Activation of Protein Kinase B/Akt, Curr Opin. Cell Biol. vol. 10, No. 2, 1998, pp. 262-267.
Franke et al., P13K: Downstream AKTion Blocks Apoptosis, Cell, vol. 88, Feb. 21, 1997, pp. 435-437.
S. Staal, Molecular Cloning of the akt Oncogene and Its Human Homologues AKT1 and AKT2: Amplification of AKT1 in a Primary Human Gastric Adenocarcinoma, Proc., Natl, Acad, Sci, USA, vol. 84, Jul. 1987, pp. 5034-5037.
Konishi et al, Molecular Cloning and characterization of a new member of the RAC protein kinase family Association of the pleckstrin homology domain of the three types of RAC protein kinase with protein kinase C subspecies and beta alpha subunits of G, 1995.
Amino acid and nucleic acid databases, Accession No. D49386, 1999.
Cargill et al, Characterization of single-nucleotide polymorphisms in coding regions of human genes Nature Genetics, Jul. 1999, vol. 22, pp. 231-238.
Cargill et al, Characterization of single-nucleotide polymorphisms in coding regions of human genes Nature Gentics, Nov. 1999, vol. 23, p. 373.
Kennedy et al., The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signalGenes and Development, Feb. 1997, vol. 11, pp. 701-713.
Liu et al., Constitutively Activated Akt-1 Is Vital for the Survival of Human Monocyte-diffrentiated Macrophages, J. Exp. Med., Jul. 2001, vol. 194, pp. 113-126.
Altschul et al., Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997, vol. 25, pp. 3389-3402.
Walker et al., Activation of protein kinase B g and n isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B f Biochemical Journal, 1998, vol. 331, pp. 299-308.
Wang et al., Regulation of Cardiomyocyte Apoptotic Signaling by Insulin-like Growth Factor I, Circ. Res., Jun. 1998, vol. 83, pp. 516-522.
Konishi et al., Molecular Cloning and Characterization of a New Member of the RAC Protein Kinase Family: Association of the Pleckstrin Homology Domain of 3 Types of RAC Protein Kinase with Protein Kinase C Subspecies and β
Clark Kenneth L.
Guo Kun
Ivashchenko Yuri D.
Pagnoni Marco
Aventis Pharmaceuticals Inc.
Falk Anne-Marie
Sgagias Magdalene K
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