Human adeno-associated virus integration site DNA and uses there

Details Human adeno-associated virus integration site DNA and uses there Human adeno-associated virus integration site DNA and uses there

1994-09-20

1996-12-03

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Vector, per se

536 235, 536 2372, C12N 1563, C12N 1512, C12N 1533

Patent

active

055807038

ABSTRACT:
The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence corresponding to a human AAV integration site, or a subsequence thereof which is site specific to the AAV integration site.

REFERENCES:
Cohen, D., et al, (1993) Nature 366, 698-701.
Katin, R. M., et al. (1991) Genomies 10, 831-834.
Kotin, R. M., et al (1992) EMBO J. 11(13), 5071-5028.
Kotin, R. M., et al (1989) Virology 170, No. 460-467.
Kotin, R. M., et al., (1990) Proc. Natl. Acad. Sci., USA 87, 2211-2215.
Samulski, R. J., et al. (1991) EMBO J. 10(12), 3941-3950.
Das, H. K., et al. (1987) J. Biol. Chem. 262(10), 4787-4793.
Kotin, R. M. et al., "Mapping and Direct Visualization of a Region-Specific Viral DNA Integration Site on Chromosome 19q13--qter," EMBL Database entry Hssatvis; Accession No. M54997 (Jul. 23, 1991).
Berns, K. I., "Parvovirus Replication," Microbiol. Rev., 54:316-329 (1990).
Samulski, F., et al., "Targeted integration of adeno-associated virus (AAV) into human chromosome 19," EMBO J., 11:1228 (1992).

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