Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2003-06-11
2009-12-08
Powers, Fiona T (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S252110, C514S252140, C514S253020, C514S253110, C544S121000, C544S336000, C544S357000
Reexamination Certificate
active
07629341
ABSTRACT:
The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
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Bannen Lynne Canne
Co Erick W.
Jammalamadaka Vasu
Kim Moon Hwan
Le Donna Tra
McDonnell Boehnen & Hulbert & Berghoff LLP
Powers Fiona T
Symphony Evolution, Inc.
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