Human acute phase response factor

Details Human acute phase response factor Human acute phase response factor

1997-11-06

1998-12-01

McKelvey, Terry A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1447

Patent

active

058440828

ABSTRACT:
Mammal transcription factor APRF, process for the preparation of it, DNAs encoding the product, replication and expression vector comprising the DNA, host cells transformed or tranfected with the replication and expression vector, evaluating and screening method for searching an inhibitory agent on the function of APRF and an inhibitory agent against the function of the APRF. The peptide of the present invention (APRF) may be useful for complement or suppression of the function of APRF, screening an inhibitory agent against the function of APRF. Inhibiting agent containing the product as active ingredient of the present invention may be also useful for treatment of diseases related to cytokine such as IL-6, i.e. inflammatory diseases.

REFERENCES:
Yuan, J. et al., "The Signalling pathways of interleukin-6 and gamma interferon convorge by the activation of different transcription factors", Mol Cell Biol, 14(3), pp. 1657-1668, Mar. 1994.
Lutticken, C. et al., "Association of transcription factor APRF and protein kinase Jaki with the interleukin-6 signal transducer gp130", Science, 263(5143), pp. 89-92. 7 Jan. 1994.
Raz, R. et al., "Acute-Phase Response Factor and Additional Members of the Interferom-Stimulated Gene Factor-s", Jour Of Biological Chem. 269, pp. 24391-24395, 1994,
"Trying on a New Pair of SH2s", Montminy, Science,vol. 261, Sep. 1993, pp. 1694-1695.
"A nuclear factor for IL-6 . . . ", Akira et al., The EMBO Journal, vol. 9, No. 6, pp. 1897-1906, 1990.
"IL-6DBP, a Nuclear Protein . . .", Poli et al. Cell, vol. 63, pp. 643-653, 1990.
"A member of the C/EBP family . . .", Kinoshita et al., Proc. Natl. Acad. vol. 89, pp. 1473-1476, 1992.
"Acute-Phase Response Factor", Wegenka et al., Molecular & Cellular Bio., vol. 13, pp. 276-288, 1993.
"Molecular Cloning of APRF . . .", Akira et al., Cell, vol. 77, pp. 63-71. 1994.
"STAT3 activation . . .", Minami et al. PNAS 93:3963, 1996.
"STAT3 and STAT4: Members . . . ", Zhong et al., Proc. Natl Acad. vol. 91, pp. 4806-4810, 1994.
"STAT3: A STAT . . .", Zhong et al., Science, vol. 264, pp. 95-98, 1994.
"The Interleukin-6-Activated. . . ", Wegenka et al., Molec. Cell. Biol., v. 14, pp. 3186-3196, 1994.
"Requirment of Serine. . .", Zhang et al., Science, v. 267, p. 1890, 1995.

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