Human ABH

Details Human ABH Human ABH

1998-02-13

1999-07-27

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 234, 536 243, 435 691, 4352523, 43525233, 4353201, 435325, C12N 1512, C12N 1562, C12N 1570, C12N 1585

Patent

active

059292253

ABSTRACT:
A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.

REFERENCES:
Lindahl et al. (1988) Ann. Rev. Biochem 57:133-157.
Kataoka et al. (1985) Mol. & Gen. Genetics 198:263-269.
Chen et al. (1989) PNAS 86:7961-7965.
Chen et al. (1994) J. Bacteriol. 176(20):6255-6261.
Kondo et al. (1986) JBC 261:15772-15777.

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