Human 7-TM receptor similar to murine frizzled-6 gene

Details Human 7-TM receptor similar to murine frizzled-6 gene Human 7-TM receptor similar to murine frizzled-6 gene

1997-12-09

1999-11-30

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 71, 435 72, 4352528, 4353201, 530350, 536 235, C07K 14705, C12N 1512

Patent

active

059940980

ABSTRACT:
hFrizzled-6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hFrizzled-6 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

REFERENCES:
Hoang et al. "Primary Structure and Tissue Distribution of FRZB, a Novel Protein Related to Drosophila Frizzled, Suggest a Role in Skeletal Morphogenesis", Journal of Biological Chemistry, vol. 271 (42), pp. 26131-26137 (1996).
Wang et al. "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is the Williams syndrome deletion at 7q11.23", Human Molecular Genetics, vol. 6 (3), pp. 465-472 (1997).
He et al. "A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A", Science, vol. 275, pp. 1652-1654.
Tokuhara et al. "Molecular Cloning of Human Frizzled-6", Biochemical and Biophysical Research Communications, vol. 243, pp. 622-627 (1998).
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Adams et al., Accession #AA385032, EMBL Database, Apr. 18, 1997.
Copy of Partial EP Search Report.
Human Genome Sciences, Corp. EST #134449.
GenBank Accession #U43319.
Wang, Y. et al., "A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled", J. Biol. Chem. 271(8), 4468-4476 (1996).
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Vinson et al. "A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains". Nature 338:263-264, Mar. 1989.

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