Human 4-1BB receptor splicing variant

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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536 235, 536 231, 4353201, 435325, 4352523, 43525411, 530350, 530395, C12N 1512, C12N 510, C07K 14705

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058742409

ABSTRACT:
The invention relates to h4-1BBSV receptor polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

REFERENCES:
patent: 5350836 (1994-09-01), Kopchick et al.
Alderson et al., 1994, "Molecular and Biological Characterization of Human 4-1BB and its Ligand," European Journal of Immunology 24:2219-2227.
Goodwin et al., 1993, "Molecular Cloning of a Ligand for the Inducible T Cell Gene 4-1BB: A Member of an Emerging Family of Cytokines with Homology to Tumor Necrosis Factor," European Journal of Immunology 23:2631-2641.
Pollok et al., 1993, "Inducible T Cell Antigen 4-1BB," Journal of Immunology 150: 771-781.
Schwarz et al., 1993, "A Receptor Induced by Lymphocyte Activation (ILA): a New Member of the Human Nerve-Growth-Factor/Tumor-Necrosis-Factor Receptor Family," Gene 134:295-298.
Alderson et al., (Medline), US Natl. Lib. of Med., No. Q75424 (Nov. 24, 1994).
Kwon et al., (Medline), US Natl. Lib. of Med., No. R70977 (Mar. 23, 1995).
Alderson et al., (Medline), US Natl. Lib. of Med., No. Q07011, Eur. J. Immunol. 24:2219-2227(1994).
Schwarz et al., (Medline), US Natl. Lib. of Med., No. JT9752, Gene 134:295-298 (1993).
Zhou et al., Immun. Ltrs. 45:67-73 (1995).

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