HTLV-I anti-sense RNA and encoded proteins

Details HTLV-I anti-sense RNA and encoded proteins HTLV-I anti-sense RNA and encoded proteins

1988-06-27

1991-03-12

Brown, Johnnie R.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 6, 514 25, 530806, C07K 1300

Patent

active

049994212

ABSTRACT:
The mRNA coded by the "anti-sense" strand of the complementary DNA produced by HTLV-I infection contains significant open reading frames. Cells infected by HTLV-I virus produce mRNA that is anti-sense to the viral RNA genome. Infected cells may produce proteins from the newly discovered mRNA. The production of the anti-sense in mRNA initiates from a newly discovered transcriptional promoter located within 1.8 kb from the 3' terminus of the viral genome. The mRNA, protein, and antibodies directed thereto can be used in the prevention, diagnosis, and treatment of HTLV-I infections.

REFERENCES:
Chem. Abs., vol. 108, 1988, 162396j, Miller et al.
Chem. Abs., vol. 109, 1988, 184446y, Goodchild et al.
Chem. Abs. 103, 32864w (1985) Okamoto et al., [Virology, 1985, 143(2), 636-9].
Proc. Natl. Acad. Sci. U.S.A., vol. 81, pp. 6202-6206 (10/1984), Kiyokawa et al.
Chem. Abs. 111(13), 110249f (1988), Gilboa [Adv. Exp. Med. Biol. 241 (Mol. Biol. Hemopoiesis) 29-33 (1988)].
Virology, 136, 338-347 (1984), Hattori et al.
J. Goodchild et al. "Inhibition of Human Immunodeficiency Virus Replication by Antisense Oligonucleotides", Proc. Natl. Acad. Sci. U.S.A. 85: 5507-5511 (Aug. 88).
R. Miller, "Human Immunodeficiency Virus May Encode a Novel Protein on the Genomic DNA Plus Strand", Science 239: 1420-1422 (Mar. 18, 1988).

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