Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-05-05
1999-01-26
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303911, 5303913, 5303871, 435188, C07K 1600, C12P 2108
Patent
active
058640207
ABSTRACT:
A novel hepatoma transmembrane kinase receptor ligand (Htk ligand) which binds to, and activates, the Htk receptor is disclosed. As examples, mouse and human Htk ligands have been identified in a variety of tissues using a soluble Htk-Fc fusion protein. The ligands have been cloned and sequenced. The invention also relates to nucleic acids encoding the ligand, methods for production and use of the ligand, and antibodies directed thereto.
REFERENCES:
Beckmann et al., "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors" EMBO Journal 13 (16) :3757-3762 (1994).
Beckmann et al., "Molecular Characterization of a Family of Ligands for Eph-related Tyrosine Kinases" Journal of Cellular Biochemistry Supplement O (18 Part A) (Abstract Only) p. E301 (1994).
Bennett et al., "Molecular Cloning of a Ligand for the EPH-related Receptor Protein Tyrosine Kinase-Htk" Blood (abstract No. 1693) 84(10) :427a (Nov. 15, 1994).
Bennett et al., "Molecular Cloning of a Ligand for the EPH-Related Receptor Protein-Tyrosine Kinase Htk" Proc. Natl. Acad. Sci. USA 92:1866-1870 (1995).
Bergemann et al., "ELF-2, a New Member of the Eph Ligand Family, Is Segmentally Expressed in Mouse Embryos in the Region of the Hindbrain and Newly Forming Somites" Molecular & Cellular Biology 15(9) :4921-4929 (1995).
Bonaldo et al., "Human expressed sequence tag for chromosome 13, 5' end of clone 17" Genbank (Release 87) (Feb. 1995).
Bonaldo, M. et al., "Human expressed sequence tag for chromosome 13, 3' end of clone 18" Genbank (Release 87) (Feb. 1995).
Cerretti et al., "Isolation of Lerk-5: A Ligand of the EPH-related Receptor Tyrosine Kinases" Molecular Immunology 32(16) :1197-1205 (1995).
Davis et al., "Ligands for EPH-Related Receptor Tyrosine Kinases. That Require Membrane Attachment or Clustering for Activity" Science 266:816-819 (Nov. 4, 1994).
Kozlosky et al., "Ligands for the Receptor Tyrosine Kinases hek and elk: Isolation of cDNAs Encoding a Family of Proteins" Oncogene 10:299-306 (1995).
Harlowe and Lane "Antibodies, A Laboratory Manual" Cold Spring Harbor Laboratory Press, USA pp. 321-323 and pp. 626-629, 1988.
Bennett Brian D.
Matthews William
Bakalyar Heather A.
Genentech Inc.
Hutzell Paula K.
Kresnak Mark T.
Lee Wendy
LandOfFree
HTK ligand does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with HTK ligand, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HTK ligand will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1451347