Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-09-05
1998-09-15
Jagannathan, Vasu S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C07H 2104
Patent
active
058080309
ABSTRACT:
An isolated hTFIIIA gene having a nucleotide sequence coding for the amino acid sequence of SEQ ID NO:1, as disclosed, and in particular the hTFIIIA gene having the nucleotide sequence of SEQ ID NO:2. The gene can be used to express a corresponding hTFIIIA protein. The gene and protein serve as transcription regulating factors, and are useful in the diagnosis or identification of hereditary disease, such as cancer or other diseases resulting from abnormal transcriptional control and, further, in analyzing the mechanisms of action thereof.
REFERENCES:
Moorefield. Purification and cloning of human transcription factor IIIA and studies of the role of upstream sequences in human 5S gene expression. Thesis Dissertation, UMI Dissertation Services, Ann Arbor, MI. Chapter 3, Apr. 1994.
Moorefield et al, J. Biol. Chem., 269(33):20857-20865 (1994).
Waldschmidt et al, Eur. J. Biochem., 196:167-176 (1990).
Stevens et al, "Gene-based STSs as the Basis for a Human Gene Map", Abstract, Acc. No. T15760 EMBL Database Entry HS760 (1994).
Okubo et al, "Gene Expression of Human Promyelotic Cell Line HL60 Before and After Induction of Differentiation. A New Application of 3' Directed cDNA Sequencing", Abstract, Acc. No. D19678, EMBL Database Entry Hsgs00633 (1994).
Moorefield et al. Purification and characterization of human TFIIIA. Journal of Cellular Biochemistry. Supp. 17A, p. 85. Abstract, Jan. 9, 1993.
Seifart et al. Purification of human transcription facotr IIIA and its interaction with a chemically synthesized gene encoding human 5 S rRNA. The Journal of Biological Chemistry. vol. 264, No. 3, pp. 1702-1709, Jan. 25, 1989.
Fujiwara Tsutomu
Ozaki Kouichi
Shimada Yoshikazu
Shin, deceased Sadahito
Takeda Satoshi
Jagannathan Vasu S.
Lathrop Brian K.
Otsuka Pharmaceutical Co. Ltd.
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